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In contrast, acetate at ≥5 mM and 10 mM of the SCFA mixture increased PPARα gene expression at 8h.\n•\tMyH7 gene expression increased at 24h in response to ≥0.5 mM of the SCFA mixture and to ≥5 mM acetate. \n•\tAcetate increased immunofluorescence signal of MyHC I at 48h, while 10 mM of the SCFA mixture increased MyHC I at 72 and decreased MyHC II immunofluorescence signal at 48h and 72h.\n•\tSCFAs, particularly in combination, show promise in promoting oxidative phenotype in muscle fibre, providing insights for enhancing muscle health in clinical conditions and among endurance athletes."}}]},{"typeName":"subject","multiple":true,"typeClass":"controlledVocabulary","value":["Medicine, Health and Life Sciences"]},{"typeName":"topicClassification","multiple":true,"typeClass":"compound","value":[{"topicClassValue":{"typeName":"topicClassValue","multiple":false,"typeClass":"primitive","value":"Skeletal muscle phenotype"}}]},{"typeName":"language","multiple":true,"typeClass":"controlledVocabulary","value":["English"]},{"typeName":"producer","multiple":true,"typeClass":"compound","value":[{"producerName":{"typeName":"producerName","multiple":false,"typeClass":"primitive","value":"Britt Otten"},"producerAffiliation":{"typeName":"producerAffiliation","multiple":false,"typeClass":"primitive","value":"Maastricht University"}}]},{"typeName":"productionDate","multiple":false,"typeClass":"primitive","value":"2024-03-07"},{"typeName":"contributor","multiple":true,"typeClass":"compound","value":[{"contributorType":{"typeName":"contributorType","multiple":false,"typeClass":"controlledVocabulary","value":"Researcher"},"contributorName":{"typeName":"contributorName","multiple":false,"typeClass":"primitive","value":"Britt Otten"}}]},{"typeName":"grantNumber","multiple":true,"typeClass":"compound","value":[{"grantNumberAgency":{"typeName":"grantNumberAgency","multiple":false,"typeClass":"primitive","value":"Province of Limburg (The Netherlands), with a grant to the Centre for Healthy Eating and Food Innovation (HEFI) of Maastricht University—Campus Venlo"}}]},{"typeName":"depositor","multiple":false,"typeClass":"primitive","value":"Otten, Britt"},{"typeName":"dateOfDeposit","multiple":false,"typeClass":"primitive","value":"2024-05-16"},{"typeName":"dateOfCollection","multiple":true,"typeClass":"compound","value":[{"dateOfCollectionStart":{"typeName":"dateOfCollectionStart","multiple":false,"typeClass":"primitive","value":"2024-02-16"},"dateOfCollectionEnd":{"typeName":"dateOfCollectionEnd","multiple":false,"typeClass":"primitive","value":"2023-09-25"}}]},{"typeName":"kindOfData","multiple":true,"typeClass":"primitive","value":["Excel, GraphPad Prism"]},{"typeName":"software","multiple":true,"typeClass":"compound","value":[{"softwareName":{"typeName":"softwareName","multiple":false,"typeClass":"primitive","value":"GraphPad Prism Project"},"softwareVersion":{"typeName":"softwareVersion","multiple":false,"typeClass":"primitive","value":"10"}}]}]},"dansDataVaultMetadata":{"displayName":"Data Vault Metadata","name":"dansDataVaultMetadata","fields":[{"typeName":"dansDataversePid","multiple":false,"typeClass":"primitive","value":"doi:10.34894/ZYZGPE"},{"typeName":"dansDataversePidVersion","multiple":false,"typeClass":"primitive","value":"1.0"},{"typeName":"dansBagId","multiple":false,"typeClass":"primitive","value":"urn:uuid:008f722c-5359-4f21-8be1-7b5f9d7d2295"},{"typeName":"dansNbn","multiple":false,"typeClass":"primitive","value":"urn:nbn:nl:ui:13-f324b1f3-5364-4a70-b83f-99869cfca6bb"}]}},"files":[{"label":"In Vitro 2.zip","restricted":false,"version":1,"datasetVersionId":27949,"dataFile":{"id":458834,"persistentId":"","filename":"In Vitro 2.zip","contentType":"application/zip","friendlyType":"ZIP Archive","filesize":2890252038,"storageIdentifier":"surf://store:1934f74f9c2-d5a4eb2895bf","rootDataFileId":-1,"checksum":{"type":"SHA-1","value":"03f01f014024a8896eb934b42da52e45aa1a4d41"},"tabularData":false,"creationDate":"2024-11-21","publicationDate":"2024-12-02","lastUpdateTime":"2024-12-02T20:04:02Z","fileAccessRequest":true}}]}}}