{"status":"OK","data":{"id":483601,"identifier":"YOMA9L","persistentUrl":"https://doi.org/10.34894/YOMA9L","protocol":"doi","authority":"10.34894","separator":"/","publisher":"DataverseNL","publicationDate":"2025-07-14","storageIdentifier":"surf://10.34894/YOMA9L","effectiveDatasetFileCountLimit":10000,"datasetFileUploadsAvailable":9999,"datasetType":"dataset","locks":[],"latestVersion":{"id":30603,"datasetId":483601,"datasetPersistentId":"doi:10.34894/YOMA9L","datasetType":"dataset","storageIdentifier":"surf://10.34894/YOMA9L","versionNumber":1,"internalVersionNumber":15,"versionMinorNumber":0,"versionState":"RELEASED","latestVersionPublishingState":"RELEASED","deaccessionLink":"","distributionDate":"2025-06-20","productionDate":"2025-02-01","lastUpdateTime":"2025-07-14T09:00:40Z","releaseTime":"2025-07-14T09:00:40Z","createTime":"2025-05-15T07:19:04Z","publicationDate":"2025-07-14","citationDate":"2025-07-14","effectiveDatasetFileCountLimit":10000,"datasetFileUploadsAvailable":9999,"license":{"name":"CC-BY-4.0","uri":"http://creativecommons.org/licenses/by/4.0","iconUri":"https://i.creativecommons.org/l/by/4.0/88x31.png"},"fileAccessRequest":true,"metadataBlocks":{"citation":{"displayName":"Citation Metadata","name":"citation","fields":[{"typeName":"title","multiple":false,"typeClass":"primitive","value":"Urinary Mitochondrial DNA as biomarker in Living Donor Kidney Transplantation"},{"typeName":"subtitle","multiple":false,"typeClass":"primitive","value":"Urinary Mitochondrial DNA Is Related to Allograft Function in Living Donor Kidney Transplantation—An Observational Study of the VAPOR-1 Cohort"},{"typeName":"author","multiple":true,"typeClass":"compound","value":[{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Nieuwenhuijs-Moeke, Gertrude"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"University Medical Center Groningen"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0000-0001-9874-2632"}}]},{"typeName":"datasetContact","multiple":true,"typeClass":"compound","value":[{"datasetContactName":{"typeName":"datasetContactName","multiple":false,"typeClass":"primitive","value":"Digital Competence Centre"},"datasetContactAffiliation":{"typeName":"datasetContactAffiliation","multiple":false,"typeClass":"primitive","value":"rug.nl"}}]},{"typeName":"dsDescription","multiple":true,"typeClass":"compound","value":[{"dsDescriptionValue":{"typeName":"dsDescriptionValue","multiple":false,"typeClass":"primitive","value":"aIschemia–reperfusion injury (IRI) is a key contributor to graft dysfunction in kidney transplantation. Cell-free mitochondrial DNA (mtDNA) is increasingly recognized as a damage-associated molecular pattern (DAMP) and biomarker in IRI, but its prognostic role in living donor kidney transplantation (LDKT) remains unclear. Methods: This post hoc analysis of the VAPOR-1 study evaluated urinary mtDNA (UmtDNA) in 57 LDKT recipients. MtDNA levels (ND1, ND6, and D-loop) were measured at five early timepoints post-transplantation using qPCR. Associations between early UmtDNA and long-term graft function, defined by estimated glomerular filtration rate (eGFR) at 1, 12, and 24 months, were analyzed. Results: Higher UmtDNA levels in the first urine after reperfusion were significantly associated with improved eGFR at 12 months and a positive change in eGFR between month 1 and 24. These associations were not attributable to urine creatinine levels or mitochondrial copy number. Conclusions: In this LDKT cohort, elevated early UmtDNA may reflect a well-functioning graft capable of clearing systemic mtDNA rather than ongoing tubular injury. These findings suggest that the biological interpretation of mtDNA as a biomarker is context-dependent and call for careful reconsideration of its role in early transplant monitoring."},"dsDescriptionDate":{"typeName":"dsDescriptionDate","multiple":false,"typeClass":"primitive","value":"2025-06-26"}}]},{"typeName":"subject","multiple":true,"typeClass":"controlledVocabulary","value":["Medicine, Health and Life Sciences"]},{"typeName":"keyword","multiple":true,"typeClass":"compound","value":[{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"ischemia reperfusion injury"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Living donor"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"kidney transplantation"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"biomarker"}}]},{"typeName":"publication","multiple":true,"typeClass":"compound","value":[{"publicationRelationType":{"typeName":"publicationRelationType","multiple":false,"typeClass":"controlledVocabulary","value":"IsSupplementTo"},"publicationCitation":{"typeName":"publicationCitation","multiple":false,"typeClass":"primitive","value":"Gartzke L, Huisman J, Spraakman N, Lira Chavez F, Struys M, Leuvenink H, Henning R, Nieuwenhuijs-Moeke G. Urinary Mitochondrial DNA Is Related to Allograft Function in Living Donor Kidney Transplantation—An Observational Study of the VAPOR-1 Cohort. Transplantology. 2025; 6(3):20. https://doi.org/10.3390/transplantology6030020"},"publicationIDType":{"typeName":"publicationIDType","multiple":false,"typeClass":"controlledVocabulary","value":"doi"},"publicationIDNumber":{"typeName":"publicationIDNumber","multiple":false,"typeClass":"primitive","value":"10.3390/transplantology6030020"},"publicationURL":{"typeName":"publicationURL","multiple":false,"typeClass":"primitive","value":"https://www.mdpi.com/2673-3943/6/3/20"}}]},{"typeName":"language","multiple":true,"typeClass":"controlledVocabulary","value":["English"]},{"typeName":"producer","multiple":true,"typeClass":"compound","value":[{"producerName":{"typeName":"producerName","multiple":false,"typeClass":"primitive","value":"Nieuwenhuijs-Moeke, Gertrude Johanna"},"producerAffiliation":{"typeName":"producerAffiliation","multiple":false,"typeClass":"primitive","value":"Department of Anesthesiology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, the Netherlands"},"producerAbbreviation":{"typeName":"producerAbbreviation","multiple":false,"typeClass":"primitive","value":"GJNM"}}]},{"typeName":"productionDate","multiple":false,"typeClass":"primitive","value":"2025-02-01"},{"typeName":"productionPlace","multiple":true,"typeClass":"primitive","value":["University Medical Center Groningen, the Netherlands"]},{"typeName":"distributor","multiple":true,"typeClass":"compound","value":[{"distributorName":{"typeName":"distributorName","multiple":false,"typeClass":"primitive","value":"DataverseNL network"},"distributorAffiliation":{"typeName":"distributorAffiliation","multiple":false,"typeClass":"primitive","value":"DANS"},"distributorAbbreviation":{"typeName":"distributorAbbreviation","multiple":false,"typeClass":"primitive","value":"DVNL"},"distributorURL":{"typeName":"distributorURL","multiple":false,"typeClass":"primitive","value":"https://dataverse.nl/"}}]},{"typeName":"distributionDate","multiple":false,"typeClass":"primitive","value":"2025-06-20"},{"typeName":"depositor","multiple":false,"typeClass":"primitive","value":"Silva Correia Alves, Ana"},{"typeName":"dateOfDeposit","multiple":false,"typeClass":"primitive","value":"2025-05-15"},{"typeName":"timePeriodCovered","multiple":true,"typeClass":"compound","value":[{"timePeriodCoveredStart":{"typeName":"timePeriodCoveredStart","multiple":false,"typeClass":"primitive","value":"2010"},"timePeriodCoveredEnd":{"typeName":"timePeriodCoveredEnd","multiple":false,"typeClass":"primitive","value":"2025"}}]},{"typeName":"dateOfCollection","multiple":true,"typeClass":"compound","value":[{"dateOfCollectionStart":{"typeName":"dateOfCollectionStart","multiple":false,"typeClass":"primitive","value":"2010"},"dateOfCollectionEnd":{"typeName":"dateOfCollectionEnd","multiple":false,"typeClass":"primitive","value":"2012"}}]},{"typeName":"kindOfData","multiple":true,"typeClass":"primitive","value":["demographic and outcome data. Mitochondrial DNA data"]},{"typeName":"software","multiple":true,"typeClass":"compound","value":[{"softwareName":{"typeName":"softwareName","multiple":false,"typeClass":"primitive","value":"MS-excel"}}]}]},"dansDataVaultMetadata":{"displayName":"Data Vault Metadata","name":"dansDataVaultMetadata","fields":[{"typeName":"dansDataversePid","multiple":false,"typeClass":"primitive","value":"doi:10.34894/YOMA9L"},{"typeName":"dansDataversePidVersion","multiple":false,"typeClass":"primitive","value":"1.0"},{"typeName":"dansBagId","multiple":false,"typeClass":"primitive","value":"urn:uuid:0579f983-bb16-4eb5-9ad7-18f5a8862674"},{"typeName":"dansNbn","multiple":false,"typeClass":"primitive","value":"urn:nbn:nl:ui:13-70ae421f-ac3b-477e-8568-a66c80cc0006"}]}},"files":[{"label":"Urinary mtDAN VAPOR-1.xlsx","restricted":false,"version":1,"datasetVersionId":30603,"dataFile":{"id":487638,"persistentId":"","filename":"Urinary mtDAN VAPOR-1.xlsx","contentType":"application/vnd.openxmlformats-officedocument.spreadsheetml.sheet","friendlyType":"MS Excel Spreadsheet","filesize":31613,"storageIdentifier":"surf://store:19797103f5b-2fdab00fd198","rootDataFileId":-1,"checksum":{"type":"SHA-1","value":"8ec6f1055c0c459c5bbbffd8672f47bf588abaad"},"tabularData":false,"creationDate":"2025-06-22","publicationDate":"2025-07-14","lastUpdateTime":"2025-07-14T09:00:40Z","fileAccessRequest":true}}]}}}