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Metadata","name":"citation","fields":[{"typeName":"title","multiple":false,"typeClass":"primitive","value":"Penetration of topically administered corticosteroids in normal equine ocular fluids"},{"typeName":"subtitle","multiple":false,"typeClass":"primitive","value":"Penetration of topically administered corticosteroids in equine ocular fluids"},{"typeName":"author","multiple":true,"typeClass":"compound","value":[{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Hermans, Hanneke"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Utrecht University"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0000-0002-7581-6683"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"van den 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University"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0000-0002-2646-9216"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Brommer, Harold"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Utrecht University"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ScopusID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"6701514238"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Boevé, Michael H."},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Utrecht University"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ScopusID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"7003909751"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Gehring, Ronette"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Utrecht University"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0000-0002-1329-201X"}}]},{"typeName":"datasetContact","multiple":true,"typeClass":"compound","value":[{"datasetContactName":{"typeName":"datasetContactName","multiple":false,"typeClass":"primitive","value":"Hermans, Hanneke"},"datasetContactAffiliation":{"typeName":"datasetContactAffiliation","multiple":false,"typeClass":"primitive","value":"Utrecht University"}}]},{"typeName":"dsDescription","multiple":true,"typeClass":"compound","value":[{"dsDescriptionValue":{"typeName":"dsDescriptionValue","multiple":false,"typeClass":"primitive","value":"Background: Topical dexamethasone and prednisolone are currently the mainstay treatment for equine ophthalmic inflammatory diseases, such as equine recurrent uveitis. Comparative pharmacokinetic studies in horses are lacking and current guidelines are mainly based on empirical data and extrapolation from other species.\nObjectives: To investigate the penetration and local concentrations of topically applied dexamethasone and prednisolone in normal equine ocular fluids and serum.\nStudy Design: Prospective randomized experimental pharmacokinetic study.  \nMethods: Twenty-one Shetland ponies without ophthalmic disease were treated bilaterally topically every 2 hours during 24 hours to obtain steady-state drug concentrations. One eye was treated with 0.15 mg dexamethasone disodium phosphate (0.1%) and the other eye was simultaneously treated with 1.5 mg prednisolone acetate (1%). Serum samples were taken prior to induction of general anaesthesia. Aqueous and vitreous humour samples were taken during euthanasia at time points after administration of the last dose (t=5min, t=15min, t=30min, t=60min, t=90 min, t=120min, t=180min). Each pony was randomly assigned to one time point and 3 ponies were sampled per time point. Dexamethasone and prednisolone concentrations were measured by liquid chromatography-mass spectrometry."}}]},{"typeName":"subject","multiple":true,"typeClass":"controlledVocabulary","value":["Medicine, Health and Life Sciences"]},{"typeName":"keyword","multiple":true,"typeClass":"compound","value":[{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"horse"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"ophthalmic"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"topical administration"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"liquid chromatography-mass spectrometry"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"corticosteroids"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"drug dosing interval"}}]},{"typeName":"publication","multiple":true,"typeClass":"compound","value":[{"publicationCitation":{"typeName":"publicationCitation","multiple":false,"typeClass":"primitive","value":"Hermans H, van den Berg EMH, Slenter IJM, Vendrig DJC, de Nijs-Tjon LL, Vernooij JCM, Brommer H, Boevé MH, Gehring R. Penetration of topically administered dexamethasone disodium phosphate and prednisolone acetate into the normal equine ocular fluids. Equine Vet J. 2021 Oct 27. doi: 10.1111/evj.13526. Epub ahead of print."},"publicationIDType":{"typeName":"publicationIDType","multiple":false,"typeClass":"controlledVocabulary","value":"doi"},"publicationIDNumber":{"typeName":"publicationIDNumber","multiple":false,"typeClass":"primitive","value":"10.1111/evj.13526"},"publicationURL":{"typeName":"publicationURL","multiple":false,"typeClass":"primitive","value":"https://doi.org/10.1111/evj.13526"}}]},{"typeName":"language","multiple":true,"typeClass":"controlledVocabulary","value":["English"]},{"typeName":"productionDate","multiple":false,"typeClass":"primitive","value":"2021-10-27"},{"typeName":"depositor","multiple":false,"typeClass":"primitive","value":"Hermans, Hanneke"},{"typeName":"dateOfDeposit","multiple":false,"typeClass":"primitive","value":"2021-10-07"},{"typeName":"kindOfData","multiple":true,"typeClass":"primitive","value":["experimental date"]},{"typeName":"software","multiple":true,"typeClass":"compound","value":[{"softwareName":{"typeName":"softwareName","multiple":false,"typeClass":"primitive","value":"Excel"},"softwareVersion":{"typeName":"softwareVersion","multiple":false,"typeClass":"primitive","value":"Windows for Mac 2011, version 14.4.7"}}]},{"typeName":"otherReferences","multiple":true,"typeClass":"primitive","value":["This investigation was carried out as an adjunct to a large orthopaedic study which was approved by the Central Authority for Scientific Procedures on Animals (CCD; project permit AVD108002015307). The Head of Animal Welfare Body Utrecht confirms the additional interventions required for the current study were permitted."]}]},"dansDataVaultMetadata":{"displayName":"Data Vault Metadata","name":"dansDataVaultMetadata","fields":[{"typeName":"dansDataversePid","multiple":false,"typeClass":"primitive","value":"doi:10.34894/XAFT9K"},{"typeName":"dansDataversePidVersion","multiple":false,"typeClass":"primitive","value":"1.0"},{"typeName":"dansBagId","multiple":false,"typeClass":"primitive","value":"urn:uuid:2fcbe304-11e4-41af-8b10-c19757264825"},{"typeName":"dansNbn","multiple":false,"typeClass":"primitive","value":"urn:nbn:nl:ui:13-c819d2ad-8e71-495d-92cb-f3c21d663bba"}]}},"files":[{"label":"Corticosteroids in horse eyeliquid serum 2019 online repository .xlsx","restricted":false,"version":1,"datasetVersionId":8881,"dataFile":{"id":192654,"persistentId":"","filename":"Corticosteroids in horse eyeliquid serum 2019 online repository .xlsx","contentType":"application/vnd.openxmlformats-officedocument.spreadsheetml.sheet","friendlyType":"MS Excel Spreadsheet","filesize":45126,"storageIdentifier":"surf://store:17c5a614103-d12519b19be9","rootDataFileId":-1,"checksum":{"type":"SHA-1","value":"2db578b45ddbffed0fec7ce33fd5286a7e0c14e7"},"tabularData":false,"creationDate":"2021-10-07","publicationDate":"2021-10-28","lastUpdateTime":"2021-10-28T09:41:26Z","fileAccessRequest":false}},{"label":"Corticostroid eye liquid LCMS online repository.xlsx","restricted":false,"version":1,"datasetVersionId":8881,"dataFile":{"id":192653,"persistentId":"","filename":"Corticostroid eye liquid LCMS online repository.xlsx","contentType":"application/vnd.openxmlformats-officedocument.spreadsheetml.sheet","friendlyType":"MS Excel Spreadsheet","filesize":22831,"storageIdentifier":"surf://store:17c5a6142f5-402e2933420e","rootDataFileId":-1,"checksum":{"type":"SHA-1","value":"d70016682d518e1e5d1b8eb58a8202b8ce2eb8d2"},"tabularData":false,"creationDate":"2021-10-07","publicationDate":"2021-10-28","lastUpdateTime":"2021-10-28T09:41:26Z","fileAccessRequest":false}},{"label":"Information animals - online repository.xlsx","restricted":false,"version":1,"datasetVersionId":8881,"dataFile":{"id":192652,"persistentId":"","filename":"Information animals - online repository.xlsx","contentType":"application/vnd.openxmlformats-officedocument.spreadsheetml.sheet","friendlyType":"MS Excel Spreadsheet","filesize":11185,"storageIdentifier":"surf://store:17c5a6141ed-62ad2bd5720b","rootDataFileId":-1,"checksum":{"type":"SHA-1","value":"f30e863f4512b0691755b03f065be1d7e3ba15a3"},"tabularData":false,"creationDate":"2021-10-07","publicationDate":"2021-10-28","lastUpdateTime":"2021-10-28T09:41:26Z","fileAccessRequest":false}}]}}}