{"status":"OK","data":{"id":318683,"identifier":"W8YBH6","persistentUrl":"https://doi.org/10.34894/W8YBH6","protocol":"doi","authority":"10.34894","separator":"/","publisher":"DataverseNL","publicationDate":"2022-11-29","storageIdentifier":"surf://10.34894/W8YBH6","effectiveDatasetFileCountLimit":10000,"datasetFileUploadsAvailable":9996,"datasetType":"dataset","locks":[],"latestVersion":{"id":24468,"datasetId":318683,"datasetPersistentId":"doi:10.34894/W8YBH6","datasetType":"dataset","storageIdentifier":"surf://10.34894/W8YBH6","versionNumber":1,"internalVersionNumber":13,"versionMinorNumber":0,"versionState":"RELEASED","latestVersionPublishingState":"RELEASED","deaccessionLink":"","lastUpdateTime":"2022-11-29T11:36:21Z","releaseTime":"2022-11-29T11:36:21Z","createTime":"2022-11-11T14:19:50Z","publicationDate":"2022-11-29","citationDate":"2022-11-29","effectiveDatasetFileCountLimit":10000,"datasetFileUploadsAvailable":9996,"termsOfUse":"The standard Data Sharing Agreement (DSA) of the UMC Utrecht must be signed without adjustments. This DSA is in compliance with Dutch law. No costs are involved.","confidentialityDeclaration":"no","specialPermissions":"To obtain access to the data, a <a href=\"https://www.umcutrecht.nl/en/data-request-form-umc-utrecht\">request form</a> has to be completed. In addition to a completed request form, a  Data Sharing Agreement (DSA) in line with GDPR regulations and/or a Research Collaboration Agreement (RCA) should be signed before data is shared. Only data requests in line with the Terms of Use will be taken into consideration. ","restrictions":"See Data Sharing Agreement.","citationRequirements":"See Data Sharing Agreement.","conditions":"To access and use the dataset please read the Terms of Use and the Terms of Access.","disclaimer":"See Data Sharing Agreement.","termsOfAccess":"By downloading or otherwise accessing the materials, the downloader represents his/her acceptance of the Terms of Use. ","fileAccessRequest":false,"metadataBlocks":{"citation":{"displayName":"Citation Metadata","name":"citation","fields":[{"typeName":"title","multiple":false,"typeClass":"primitive","value":"Replication Data for: \"Comparison of cardiovascular biomarker expression in extracellular vesicles, plasma and carotid plaque for the prediction of MACE in CEA patients.\""},{"typeName":"author","multiple":true,"typeClass":"compound","value":[{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Maarten C. Verwer"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"UMC Utrecht"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0000-0002-32389706"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Sander W. van der Laan"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"UMC Utrecht"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0000-0001-6888-1404"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Gert Jan de Borst"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"UMC Utrecht"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Dominique P.V. de Kleijn"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"UMC Utrecht"}}]},{"typeName":"datasetContact","multiple":true,"typeClass":"compound","value":[{"datasetContactName":{"typeName":"datasetContactName","multiple":false,"typeClass":"primitive","value":"dLAB Data management"},"datasetContactAffiliation":{"typeName":"datasetContactAffiliation","multiple":false,"typeClass":"primitive","value":"UMC Utrecht"}},{"datasetContactName":{"typeName":"datasetContactName","multiple":false,"typeClass":"primitive","value":"Maarten C. Verwer"},"datasetContactAffiliation":{"typeName":"datasetContactAffiliation","multiple":false,"typeClass":"primitive","value":"UMC Utrecht"}},{"datasetContactName":{"typeName":"datasetContactName","multiple":false,"typeClass":"primitive","value":"Sander W. van der Laan"},"datasetContactAffiliation":{"typeName":"datasetContactAffiliation","multiple":false,"typeClass":"primitive","value":"UMC Utrecht"}}]},{"typeName":"dsDescription","multiple":true,"typeClass":"compound","value":[{"dsDescriptionValue":{"typeName":"dsDescriptionValue","multiple":false,"typeClass":"primitive","value":"<strong>Abstract</strong></br>\nExtracellular vesicles (EV) are an emerging biomarker source for diagnosis and prognosis of cardiovascular disease. A protein comparison of plasma EVs in relation to blood plasma and atherosclerotic plaque has not been performed but would provide insight into the origin and content of biomarker sources, and their association with atherosclerotic progression. Using samples of 88 carotid endarterectomy patients in the <a href=\"https://doi.org/10.34894/4IKE3T\" target=\"_blank\">Athero-Express</a>, 92 proteins (Olink Cardiovascular III panel) were measured in citrate plasma, plasma derived LDL-EVs and atherosclerotic plaque. Proteins were correlated between sources and were related to occurrence of pre-operative stroke and three-year major adverse cardiovascular events (MACE). Plasma and EV proteins correlated moderately on average, but with substantial variability. Plasma and EVs showed little correlation with plaque, suggesting that these circulating biomarkers may not originate from the latter. Plaque (n = 17) contained most differentially-expressed proteins in patients with stroke, opposed to EVs (n = 6) and plasma (n = 5). In contrast, EVs contained most differentially-expressed proteins for MACE (n = 21) compared to plasma (n = 9) and plaque (n = 1). EVs appear to provide additional information about severity and progression of systemic atherosclerosis than can be obtained from plasma or atherosclerotic plaque.</br>\n</br>\nEthical approval for this study (TME/C-01.18) was provided by the Medical Research Ethics Committee of University Medical Center Utrecht, Utrecht, The Netherlands on 10 April 2002, and all research was conducted according to the principles of the Declaration of Helsinki (59th amendment, Seoul 2008) and in accordance with the Dutch Medical Research Involving Human Subjects Act (WMO). </br>\n</br>\n<b>Important notice on availability of data</b></br>\nThere are restrictions on use by commercial parties, and on sharing openly based on (inter)national laws and regulations and the written informed consent. Therefore these data (and additional clinical data) are only available upon discussion and signing a Data Sharing Agreement (see Terms of Access) and within a specially designed UMC Utrecht provided environment.</br></br>"}}]},{"typeName":"subject","multiple":true,"typeClass":"controlledVocabulary","value":["Medicine, Health and Life Sciences"]},{"typeName":"keyword","multiple":true,"typeClass":"compound","value":[{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"atherosclerosis"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"plaque"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"endarterectomy"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"OLINK"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"extracellular vesicles"}}]},{"typeName":"publication","multiple":true,"typeClass":"compound","value":[{"publicationCitation":{"typeName":"publicationCitation","multiple":false,"typeClass":"primitive","value":"<a href=\"\" target=\"_blank\">Verwer, M. C. <em>et al.</em></a> Comparison of cardiovascular biomarker expression in extracellular vesicles, plasma and carotid plaque for the prediction of MACE in CEA patients. <strong>Journal</strong> 2022.</br>"}}]},{"typeName":"depositor","multiple":false,"typeClass":"primitive","value":"Sander W. van der Laan"},{"typeName":"dateOfDeposit","multiple":false,"typeClass":"primitive","value":"2022-11-11"}]},"dansDataVaultMetadata":{"displayName":"Data Vault Metadata","name":"dansDataVaultMetadata","fields":[{"typeName":"dansDataversePid","multiple":false,"typeClass":"primitive","value":"doi:10.34894/W8YBH6"},{"typeName":"dansDataversePidVersion","multiple":false,"typeClass":"primitive","value":"1.0"},{"typeName":"dansBagId","multiple":false,"typeClass":"primitive","value":"urn:uuid:313ae77e-9bc0-494e-bbab-2329d1af078a"},{"typeName":"dansNbn","multiple":false,"typeClass":"primitive","value":"urn:nbn:nl:ui:13-ab328781-d0d3-4e67-80cf-41009e407a79"}]}},"files":[{"description":"Approval Medical Ethics Committee","label":"20020410_Approval_Protocol_TME_Athero-Express_Biobank_Study.pdf","restricted":true,"version":2,"datasetVersionId":24468,"dataFile":{"id":318686,"persistentId":"","filename":"20020410_Approval_Protocol_TME_Athero-Express_Biobank_Study.pdf","contentType":"application/pdf","friendlyType":"Adobe PDF","filesize":61663,"description":"Approval Medical Ethics Committee","storageIdentifier":"surf://store:184670de327-7fe124a5cbed","rootDataFileId":-1,"checksum":{"type":"SHA-1","value":"7af1184782ed6d4c33f554077390c88f0ab184b4"},"tabularData":false,"creationDate":"2022-11-11","publicationDate":"2022-11-29","lastUpdateTime":"2022-11-29T11:36:21Z","fileAccessRequest":false}},{"description":"Datamanagement plan","label":"20211007_DMP_Athero-Express_Biobank_Study.pdf","restricted":true,"version":2,"datasetVersionId":24468,"dataFile":{"id":318685,"persistentId":"","filename":"20211007_DMP_Athero-Express_Biobank_Study.pdf","contentType":"application/pdf","friendlyType":"Adobe PDF","filesize":64158,"description":"Datamanagement plan","storageIdentifier":"surf://store:184670de41d-cc736b87100c","rootDataFileId":-1,"checksum":{"type":"SHA-1","value":"a733a0cddb4a49961748170591890e5aa47494d1"},"tabularData":false,"creationDate":"2022-11-11","publicationDate":"2022-11-29","lastUpdateTime":"2022-11-29T11:36:21Z","fileAccessRequest":false}},{"description":"Latest version of informed consent form","label":"Athero-Express_Biobank_Study_IC_versie_4.doc","restricted":true,"version":2,"datasetVersionId":24468,"dataFile":{"id":318684,"persistentId":"","filename":"Athero-Express_Biobank_Study_IC_versie_4.doc","contentType":"application/msword","friendlyType":"MS Word","filesize":34816,"description":"Latest version of informed consent form","storageIdentifier":"surf://store:184670de4cc-88a194ca1726","rootDataFileId":-1,"checksum":{"type":"SHA-1","value":"40b3106353e85b47a9d1185093e95d91bceea03b"},"tabularData":false,"creationDate":"2022-11-11","publicationDate":"2022-11-29","lastUpdateTime":"2022-11-29T11:36:21Z","fileAccessRequest":false}},{"description":"README","label":"README.txt","restricted":false,"version":1,"datasetVersionId":24468,"dataFile":{"id":318689,"persistentId":"","filename":"README.txt","contentType":"text/plain","friendlyType":"Plain Text","filesize":2937,"description":"README","storageIdentifier":"surf://store:184674912cf-6d43d309aeaf","rootDataFileId":-1,"checksum":{"type":"SHA-1","value":"64afe133a99d5e24b3462d6acb9e9fe3835adba1"},"tabularData":false,"creationDate":"2022-11-11","publicationDate":"2022-11-29","lastUpdateTime":"2022-11-29T11:36:21Z","fileAccessRequest":false}}]}}}