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In this thesis we constructed several new biosynthetic pathways, combining RiPP post-translational modification enzymes to act on a single peptide to synthesize new-to-nature antimicrobial peptides that mimic several potent non-ribosomal peptide antibiotics. These files contains data belonging to the three experimental chapters of the thesis and include mass spectrometry figures, LC-MS analysis figures, precursor peptide sequences, primer sequences and the supplementary information references."},"dsDescriptionDate":{"typeName":"dsDescriptionDate","multiple":false,"typeClass":"primitive","value":"2023"}}]},{"typeName":"subject","multiple":true,"typeClass":"controlledVocabulary","value":["Chemistry","Medicine, Health and Life Sciences"]},{"typeName":"keyword","multiple":true,"typeClass":"compound","value":[{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"RiPPs"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"NRPS"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Antibiotics"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Synthetic biology"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Modification enzymes"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Peptides"}}]},{"typeName":"topicClassification","multiple":true,"typeClass":"compound","value":[{"topicClassValue":{"typeName":"topicClassValue","multiple":false,"typeClass":"primitive","value":"Synthetic biology"}},{"topicClassValue":{"typeName":"topicClassValue","multiple":false,"typeClass":"primitive","value":"Molecular biology"}}]},{"typeName":"publication","multiple":true,"typeClass":"compound","value":[{"publicationCitation":{"typeName":"publicationCitation","multiple":false,"typeClass":"primitive","value":"Combinatorial RiPP biosynthesis for the generation of gene-encoded new-to-nature peptide antimicrobials. / Ruijne, Fleur.\n[Groningen]: University of Groningen, 2023. 320 p."},"publicationIDType":{"typeName":"publicationIDType","multiple":false,"typeClass":"controlledVocabulary","value":"handle"},"publicationIDNumber":{"typeName":"publicationIDNumber","multiple":false,"typeClass":"primitive","value":"11370/c9bb3339-ef14-4e8f-abf2-23a265c45426"},"publicationURL":{"typeName":"publicationURL","multiple":false,"typeClass":"primitive","value":"https://hdl.handle.net/11370/c9bb3339-ef14-4e8f-abf2-23a265c45426"}}]},{"typeName":"language","multiple":true,"typeClass":"controlledVocabulary","value":["English"]},{"typeName":"distributor","multiple":true,"typeClass":"compound","value":[{"distributorName":{"typeName":"distributorName","multiple":false,"typeClass":"primitive","value":"DataverseNL"}}]},{"typeName":"depositor","multiple":false,"typeClass":"primitive","value":"Silva Correia Alves, Ana"},{"typeName":"dateOfDeposit","multiple":false,"typeClass":"primitive","value":"2023-04-26"}]},"dansDataVaultMetadata":{"displayName":"Data Vault Metadata","name":"dansDataVaultMetadata","fields":[{"typeName":"dansDataversePid","multiple":false,"typeClass":"primitive","value":"doi:10.34894/V5O7UE"},{"typeName":"dansDataversePidVersion","multiple":false,"typeClass":"primitive","value":"2.0"},{"typeName":"dansBagId","multiple":false,"typeClass":"primitive","value":"urn:uuid:e78e56b7-7b8e-4bff-b5cd-7418906acf62"},{"typeName":"dansNbn","multiple":false,"typeClass":"primitive","value":"urn:nbn:nl:ui:13-ed8df0e7-0b70-4ebd-b6d3-91a3ef4f6b57"}]}},"files":[{"label":"Thesis_selected supporting information figures_FINAL.pdf","restricted":false,"version":1,"datasetVersionId":25340,"dataFile":{"id":381675,"persistentId":"","filename":"Thesis_selected supporting information figures_FINAL.pdf","contentType":"application/pdf","friendlyType":"Adobe PDF","filesize":12054118,"storageIdentifier":"surf://store:18a89f2d626-dfee3ecf5ef8","rootDataFileId":-1,"checksum":{"type":"SHA-1","value":"dcc3eb31ade2d9d9aba8a7be891fa643d1d3e605"},"tabularData":false,"creationDate":"2023-09-12","publicationDate":"2023-09-14","lastUpdateTime":"2023-09-14T07:27:38Z","fileAccessRequest":false}}]}}}