{"status":"OK","data":{"id":217794,"identifier":"TWMP7M","persistentUrl":"https://doi.org/10.34894/TWMP7M","protocol":"doi","authority":"10.34894","separator":"/","publisher":"DataverseNL","publicationDate":"2022-02-14","storageIdentifier":"surf://10.34894/TWMP7M","effectiveDatasetFileCountLimit":10000,"datasetFileUploadsAvailable":9997,"datasetType":"dataset","locks":[],"latestVersion":{"id":13070,"datasetId":217794,"datasetPersistentId":"doi:10.34894/TWMP7M","datasetType":"dataset","storageIdentifier":"surf://10.34894/TWMP7M","versionNumber":1,"internalVersionNumber":14,"versionMinorNumber":0,"versionState":"RELEASED","latestVersionPublishingState":"RELEASED","deaccessionLink":"","lastUpdateTime":"2022-02-14T14:35:16Z","releaseTime":"2022-02-14T14:35:16Z","createTime":"2022-01-04T14:45:53Z","publicationDate":"2022-02-14","citationDate":"2022-02-14","effectiveDatasetFileCountLimit":10000,"datasetFileUploadsAvailable":9997,"termsOfUse":"This dataset is made available without information on how it can be used. You should communicate with the Contact(s) specified before use.","fileAccessRequest":true,"metadataBlocks":{"citation":{"displayName":"Citation Metadata","name":"citation","fields":[{"typeName":"title","multiple":false,"typeClass":"primitive","value":"Task-induced subjective fatigue and resting-state striatal connectivity following traumatic brain injury"},{"typeName":"author","multiple":true,"typeClass":"compound","value":[{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Bruijel, J."},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Maastricht University"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0000-0002-2656-5152"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Quaedflieg, C.W.E.M."},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Maastricht University"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0000-0003-1769-5438"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Otto, T."},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Maastricht University"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0000-0001-5892-1388"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"van de Ven, V."},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Maastricht University"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0000-0001-8735-3711"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Stapert, S.Z."},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Maastricht University"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0000-0001-7041-7643"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"van Heugten, C."},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Maastricht University"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0000-0003-4272-7315"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Vermeeren, A."},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Maastricht University"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0000-0002-9504-1184"}}]},{"typeName":"datasetContact","multiple":true,"typeClass":"compound","value":[{"datasetContactName":{"typeName":"datasetContactName","multiple":false,"typeClass":"primitive","value":"faculty data manager FPN"},"datasetContactAffiliation":{"typeName":"datasetContactAffiliation","multiple":false,"typeClass":"primitive","value":"Maastricht University"}},{"datasetContactName":{"typeName":"datasetContactName","multiple":false,"typeClass":"primitive","value":"Bruijel, J."},"datasetContactAffiliation":{"typeName":"datasetContactAffiliation","multiple":false,"typeClass":"primitive","value":"Maastricht University"}}]},{"typeName":"dsDescription","multiple":true,"typeClass":"compound","value":[{"dsDescriptionValue":{"typeName":"dsDescriptionValue","multiple":false,"typeClass":"primitive","value":"Background: People with traumatic brain injury (TBI) often experience fatigue, but an understanding of the neural underpinnings of fatigue following TBI is still lacking. This study used resting-state functional magnetic resonance imaging (rs-fMRI) to examine associations between functional connectivity (FC) changes and task-induced changes in subjective fatigue in people with moderate-severe TBI.\nMethods: Sixteen people with moderate-severe TBI and 17 matched healthy controls (HC) performed an adaptive N-back task (working memory task) to induce cognitive fatigue. Before and after the task they rated their state fatigue level and underwent rs-fMRI. Seed-to-voxel analyses with seeds in areas involved in cognitive fatigue, namely the striatum and default mode network (DMN) including, medial prefrontal cortex and posterior cingulate cortex, were performed.\nResults: The adaptive N-back task was effective in inducing fatigue in both groups. Subjective task-induced fatigue was positively associated with FC between striatum and precuneus in people with TBI, while there was a negative association in HC. In contrast, subjective task-induced fatigue was negatively associated with FC between striatum and cerebellum in the TBI group, while there was no association in HC. Similar associations between task-induced subjective fatigue and DMN FC were found across the groups.\nConclusions: Our results suggest that the subjective experience of fatigue was linked to DMN connectivity in both groups and was differently associated with striatal connectivity in people with moderate-severe TBI compared to HC. Defining fatigue-induced neuronal network changes is pertinent to the development of treatments that target abnormal neuronal activity after TBI."}}]},{"typeName":"subject","multiple":true,"typeClass":"controlledVocabulary","value":["Social Sciences"]},{"typeName":"keyword","multiple":true,"typeClass":"compound","value":[{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Default mode network (DMN)"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Fatigue"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Functional connectivity"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Resting-state fMRI"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Striatum"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Traumatic brain injury (TBI)"}}]},{"typeName":"depositor","multiple":false,"typeClass":"primitive","value":"Faculty of Psychology and Neuroscience - Maastricht University"},{"typeName":"dateOfDeposit","multiple":false,"typeClass":"primitive","value":"2022-01-04"},{"typeName":"kindOfData","multiple":true,"typeClass":"primitive","value":["fMRI data","Survey data","Task data"]}]},"dansDataVaultMetadata":{"displayName":"Data Vault Metadata","name":"dansDataVaultMetadata","fields":[{"typeName":"dansDataversePid","multiple":false,"typeClass":"primitive","value":"doi:10.34894/TWMP7M"},{"typeName":"dansDataversePidVersion","multiple":false,"typeClass":"primitive","value":"1.0"},{"typeName":"dansBagId","multiple":false,"typeClass":"primitive","value":"urn:uuid:6ae17902-cb22-4928-98dd-116019d7e415"},{"typeName":"dansNbn","multiple":false,"typeClass":"primitive","value":"urn:nbn:nl:ui:13-506d2224-5729-4e18-b2eb-027ac2b48fe6"}]}},"files":[{"label":"MRIF_data_Fatigue_long.csv","restricted":true,"version":1,"datasetVersionId":13070,"dataFile":{"id":223563,"persistentId":"","filename":"MRIF_data_Fatigue_long.csv","contentType":"text/csv","friendlyType":"Comma Separated Values","filesize":2914,"storageIdentifier":"surf://store:17ef859384b-92d6c995395e","rootDataFileId":-1,"checksum":{"type":"SHA-1","value":"ae1244dc4b0bf32dc84c1410e160a02f83adff2b"},"tabularData":false,"creationDate":"2022-02-14","publicationDate":"2022-02-14","lastUpdateTime":"2022-02-14T14:35:16Z","fileAccessRequest":true}},{"label":"MRIF_data_questionaire_FC_publish.csv","restricted":true,"version":1,"datasetVersionId":13070,"dataFile":{"id":223581,"persistentId":"","filename":"MRIF_data_questionaire_FC_publish.csv","contentType":"text/csv","friendlyType":"Comma Separated Values","filesize":24990,"storageIdentifier":"surf://store:17ef88edfd6-e7976f69f351","rootDataFileId":-1,"checksum":{"type":"SHA-1","value":"3d94820c9db16558012df74298b296640f1d26cd"},"tabularData":false,"creationDate":"2022-02-14","publicationDate":"2022-02-14","lastUpdateTime":"2022-02-14T14:35:16Z","fileAccessRequest":true}},{"label":"MRIF_rsFC_longFormat.csv","restricted":true,"version":1,"datasetVersionId":13070,"dataFile":{"id":223562,"persistentId":"","filename":"MRIF_rsFC_longFormat.csv","contentType":"text/csv","friendlyType":"Comma Separated Values","filesize":6734,"storageIdentifier":"surf://store:17ef8593961-b57964810d62","rootDataFileId":-1,"checksum":{"type":"SHA-1","value":"1b9015628c31003b8381edb15103ee66a7c6ef90"},"tabularData":false,"creationDate":"2022-02-14","publicationDate":"2022-02-14","lastUpdateTime":"2022-02-14T14:35:16Z","fileAccessRequest":true}}]}}}