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The intermittent and continuous Theta Burst Stimulation (iTBS and cTBS) protocols have been shown to induce opposite after-effects on human cortex excitability. Animal studies have implicated synaptic plasticity mechanisms long-term potentiation (LTP, for iTBS) and depression (LTD, for cTBS). However, the neural basis of TMS effects has not yet been studied in human neuronal cells, in particular at the level of gene expression and synaptogenesis.  To investigate responses to TBS in living human neurons, we differentiated human SH-SY5Y cells towards a mature neural phenotype, and stimulated them with iTBS, cTBS, or sham (placebo) TBS. Changes in a) mRNA expression of a set of target genes (previously associated with synaptic plasticity), and b) morphological parameters of neurite outgrowth following TBS were quantified. 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