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However, subsequent in vivo results on antibacterial efficacy were inconsistent. Therefore, this study aimed to enhance the antibacterial efficacy of the coating by increasing PEL concentration twofold (from PEL-10 to PEL-20), elevating HA levels fivefold (from HA-1 to HA-5), and/or adding polyarginine (PAR30-4). These four coating formulations underwent in vitro safety and antibacterial efficacy assessments based on Safe-by-Design (SbD) principles. In vitro testing included bacterial adhesion, osteoblast behavior, and immune response evaluations."}}]},{"typeName":"subject","multiple":true,"typeClass":"controlledVocabulary","value":["Medicine, Health and Life Sciences"]},{"typeName":"publication","multiple":true,"typeClass":"compound","value":[{"publicationRelationType":{"typeName":"publicationRelationType","multiple":false,"typeClass":"controlledVocabulary","value":"IsSupplementTo"},"publicationCitation":{"typeName":"publicationCitation","multiple":false,"typeClass":"primitive","value":"Iterative Safe-by-Design Development of an Antibacterial Coating: Balancing Efficacy and Safety for Prosthetic Joint Infection Prevention.\n\nManuscript is submitted to PLOS One."}}]},{"typeName":"depositor","multiple":false,"typeClass":"primitive","value":"Maastricht University"},{"typeName":"dateOfDeposit","multiple":false,"typeClass":"primitive","value":"2026-04-23"}]},"dansDataVaultMetadata":{"displayName":"Data Vault Metadata","name":"dansDataVaultMetadata","fields":[{"typeName":"dansDataversePid","multiple":false,"typeClass":"primitive","value":"doi:10.34894/QTX77O"},{"typeName":"dansDataversePidVersion","multiple":false,"typeClass":"primitive","value":"2.0"},{"typeName":"dansBagId","multiple":false,"typeClass":"primitive","value":"urn:uuid:0238be10-4939-45f3-b74c-65e152ce2cfe"},{"typeName":"dansNbn","multiple":false,"typeClass":"primitive","value":"urn:nbn:nl:ui:13-c8c4e269-f7e7-47e2-b834-ca49f60242b8"}]}},"files":[{"label":"Data repository.xlsx","restricted":true,"version":2,"datasetVersionId":34407,"dataFile":{"id":635814,"persistentId":"","filename":"Data repository.xlsx","contentType":"application/vnd.openxmlformats-officedocument.spreadsheetml.sheet","friendlyType":"MS Excel Spreadsheet","filesize":31030,"storageIdentifier":"surf://store:19dfca30e71-f04614190aa3","rootDataFileId":-1,"checksum":{"type":"SHA-1","value":"e716295b6be4a811d9e736842c8765e40d61eba6"},"tabularData":false,"creationDate":"2026-05-06","publicationDate":"2026-05-07","lastUpdateTime":"2026-05-07T07:00:53Z","fileAccessRequest":true}}]}}}