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Kuiper et al. 2021 \"A serum protein network predicts the early need for systemic immunomodulatory therapy in non-infectious uveitis\"
see preprint on MedRxiv\n

\nThis dataset contains:

\n
\n\n
Supplemental Table 1-3
\n\n\n
Raw SOMAscan data
\n\n\n
R scripts with step-by-step analyses
\n\n
Metadata used in the R scripts (above)
\n
"},"dsDescriptionDate":{"typeName":"dsDescriptionDate","multiple":false,"typeClass":"primitive","value":"2021-09-07"}}]},{"typeName":"subject","multiple":true,"typeClass":"controlledVocabulary","value":["Medicine, Health and Life Sciences"]},{"typeName":"keyword","multiple":true,"typeClass":"compound","value":[{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Uveitis"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"SOMAscan"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Neutrophil"}}]},{"typeName":"publication","multiple":true,"typeClass":"compound","value":[{"publicationCitation":{"typeName":"publicationCitation","multiple":false,"typeClass":"primitive","value":"This work has been published as a preprint on medrxiv:"},"publicationIDType":{"typeName":"publicationIDType","multiple":false,"typeClass":"controlledVocabulary","value":"url"},"publicationURL":{"typeName":"publicationURL","multiple":false,"typeClass":"primitive","value":"https://medrxiv.org/cgi/content/short/2021.09.22.21263286v1"}}]},{"typeName":"notesText","multiple":false,"typeClass":"primitive","value":"Objective biomarkers that can predict a severe disease course of autoimmune uveitis are lacking, and warranted for early identification of high-risk patients to improve visual outcome. The need for non-steroid immunomodulatory therapy (IMT) to control autoimmune uveitis is indicative of a more severe disease course. We used aptamer-based proteomics and a bioinformatic pipeline to uncover the serum protein network of 52 treatment-free patients and 26 healthy controls, and validation cohorts of 114 and 67 patients. Network-based analyses identified a highly co-expressed serum signature (n=85 proteins) whose concentration was consistently low in controls, but varied between cases. Patients that were positive for the signature at baseline showed a significantly increased risk for IMT during follow-up, independent of anatomical location of disease. In an independent cohort (n=114), we established robust risk categories and confirmed that patients with high levels of the signature at diagnosis had a significantly increased risk to start IMT during follow-up. Finally, we further validated the predictive association of the signature in a third cohort of 67 treatment-naive North-American patients. A serum protein signature was highly predictive for IMT in human autoimmune uveitis and may serve as an objective blood biomarker to aid in clinical-decision making."},{"typeName":"language","multiple":true,"typeClass":"controlledVocabulary","value":["English"]},{"typeName":"producer","multiple":true,"typeClass":"compound","value":[{"producerName":{"typeName":"producerName","multiple":false,"typeClass":"primitive","value":"Jonas Kuiper"},"producerAffiliation":{"typeName":"producerAffiliation","multiple":false,"typeClass":"primitive","value":"University Medical Center Utrecht"},"producerAbbreviation":{"typeName":"producerAbbreviation","multiple":false,"typeClass":"primitive","value":"UMCU"},"producerURL":{"typeName":"producerURL","multiple":false,"typeClass":"primitive","value":"https://www.umcutrecht.nl/en/research/researchers/kuiper-jonas-jjw"}}]},{"typeName":"productionDate","multiple":false,"typeClass":"primitive","value":"2021-09-07"},{"typeName":"productionPlace","multiple":true,"typeClass":"primitive","value":["Utrecht, The Netherlands"]},{"typeName":"grantNumber","multiple":true,"typeClass":"compound","value":[{"grantNumberAgency":{"typeName":"grantNumberAgency","multiple":false,"typeClass":"primitive","value":"AstraZeneca"},"grantNumberValue":{"typeName":"grantNumberValue","multiple":false,"typeClass":"primitive","value":"UMCU-MED"}}]},{"typeName":"depositor","multiple":false,"typeClass":"primitive","value":"Kuiper, Jonas"},{"typeName":"dateOfDeposit","multiple":false,"typeClass":"primitive","value":"2021-09-07"},{"typeName":"timePeriodCovered","multiple":true,"typeClass":"compound","value":[{"timePeriodCoveredStart":{"typeName":"timePeriodCoveredStart","multiple":false,"typeClass":"primitive","value":"2011-01-01"},"timePeriodCoveredEnd":{"typeName":"timePeriodCoveredEnd","multiple":false,"typeClass":"primitive","value":"2021-09-07"}}]},{"typeName":"kindOfData","multiple":true,"typeClass":"primitive","value":["Somalogic 1.3K array data of serum","Neutrophil blood count (c_b_neu) generated by CELL-DYN Sapphire System","Neutrophil blood count generated by Sysmex XN-3000 automated haematology analyser"]},{"typeName":"software","multiple":true,"typeClass":"compound","value":[{"softwareName":{"typeName":"softwareName","multiple":false,"typeClass":"primitive","value":"R studio"},"softwareVersion":{"typeName":"softwareVersion","multiple":false,"typeClass":"primitive","value":"R version 4.0.3 (2020-10-10)"}}]}]},"dansDataVaultMetadata":{"displayName":"Data Vault Metadata","name":"dansDataVaultMetadata","fields":[{"typeName":"dansDataversePid","multiple":false,"typeClass":"primitive","value":"doi:10.34894/QR1VFZ"},{"typeName":"dansDataversePidVersion","multiple":false,"typeClass":"primitive","value":"2.0"},{"typeName":"dansBagId","multiple":false,"typeClass":"primitive","value":"urn:uuid:39613000-1b02-45e0-a7b3-c34e23c3ebe0"},{"typeName":"dansNbn","multiple":false,"typeClass":"primitive","value":"urn:nbn:nl:ui:13-5b5a71aa-4e17-4445-ae95-bbaa2308bd6b"}]}},"files":[{"description":"This is a excel table with the protein copy numbers of primary human immune cells extracted from supplemental data of the manuscript by Rieckmann et al. 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