{"status":"OK","data":{"id":199090,"identifier":"PT05Q8","persistentUrl":"https://doi.org/10.34894/PT05Q8","protocol":"doi","authority":"10.34894","separator":"/","publisher":"DataverseNL","publicationDate":"2021-11-15","storageIdentifier":"surf://10.34894/PT05Q8","effectiveDatasetFileCountLimit":10000,"datasetFileUploadsAvailable":9995,"datasetType":"dataset","locks":[],"latestVersion":{"id":9417,"datasetId":199090,"datasetPersistentId":"doi:10.34894/PT05Q8","datasetType":"dataset","storageIdentifier":"surf://10.34894/PT05Q8","versionNumber":1,"internalVersionNumber":5,"versionMinorNumber":3,"versionState":"RELEASED","latestVersionPublishingState":"RELEASED","deaccessionLink":"","lastUpdateTime":"2021-11-18T13:24:42Z","releaseTime":"2021-11-18T13:24:42Z","createTime":"2021-11-18T13:24:37Z","publicationDate":"2021-11-15","citationDate":"2021-11-15","effectiveDatasetFileCountLimit":10000,"datasetFileUploadsAvailable":9995,"termsOfUse":"The standard Data Sharing Agreement (DSA) of the UMC Utrecht must be signed without adjustments. 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","restrictions":"See Data Sharing Agreement","citationRequirements":"See Data Sharing Agreemen","depositorRequirements":"See Data Sharing Agreement\n","conditions":" To access and use the dataset please read the Terms of Use and the Terms of Access","termsOfAccess":" By downloading or otherwise accessing the materials, the downloader represents his/her acceptance of the Terms of Use.\n","fileAccessRequest":false,"metadataBlocks":{"citation":{"displayName":"Citation Metadata","name":"citation","fields":[{"typeName":"title","multiple":false,"typeClass":"primitive","value":"Proton pump inhibition for secondary hemochromatosis in hereditary anemia, a phase III placebo-controlled randomized cross-over clinical trial."},{"typeName":"subtitle","multiple":false,"typeClass":"primitive","value":"PPI Shine Again"},{"typeName":"alternativeTitle","multiple":true,"typeClass":"primitive","value":["Maagzuurremmers voor de behandeling van secundaire hemochromatose bij patiënten met erfelijke niet-transfusie afhankelijke bloedarmoedes."]},{"typeName":"alternativeURL","multiple":false,"typeClass":"primitive","value":"https://www.trialregister.nl/trial/6659"},{"typeName":"author","multiple":true,"typeClass":"compound","value":[{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"van Vuren, Annelies"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"umcutrecht.nl"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0000-0002-4258-3836"}}]},{"typeName":"datasetContact","multiple":true,"typeClass":"compound","value":[{"datasetContactName":{"typeName":"datasetContactName","multiple":false,"typeClass":"primitive","value":"van Vuren, Annelies"},"datasetContactAffiliation":{"typeName":"datasetContactAffiliation","multiple":false,"typeClass":"primitive","value":"umcutrecht.nl"}},{"datasetContactName":{"typeName":"datasetContactName","multiple":false,"typeClass":"primitive","value":"van Beers, Eduard"},"datasetContactAffiliation":{"typeName":"datasetContactAffiliation","multiple":false,"typeClass":"primitive","value":"umcutrecht.nl"}},{"datasetContactName":{"typeName":"datasetContactName","multiple":false,"typeClass":"primitive","value":"Vianen, Marieke"},"datasetContactAffiliation":{"typeName":"datasetContactAffiliation","multiple":false,"typeClass":"primitive","value":"umcutrecht.nl"}}]},{"typeName":"dsDescription","multiple":true,"typeClass":"compound","value":[{"dsDescriptionValue":{"typeName":"dsDescriptionValue","multiple":false,"typeClass":"primitive","value":"Iron overload is a severe general complication of hereditary anemias. Treatment with iron chelators is hampered by important side-effects, high costs and the lack of availability in many countries with high prevalence of hereditary anemias.\nObjective: to investigate the safety and efficacy of esomeprazole in treatment of iron overload in patients with non-transfusion-dependent hereditary anemias.\nDesign: phase III randomized placebo-controlled cross-over trial.\nSetting: enrollment from March 2018 through April 2019 in five centers of expertise in the Netherlands.\nParticipants: 30 adult patients with mild-to-moderate iron overload were enrolled (non-transfusion-dependent thalassemia (N=13), pyruvate kinase deficiency (N=8), congenital sideroblastic anemia (N=3), congenital dyserythropoietic anemia (N=3), sickle cell disease (N=2), and hereditary elliptocytosis (N=1)). \nIntervention: esomeprazole 40mg BID and placebo for 12 months in a cross-over design.\nPrimary outcome: change of liver iron content (LIC) measured by MRI."}}]},{"typeName":"subject","multiple":true,"typeClass":"controlledVocabulary","value":["Medicine, Health and Life Sciences"]},{"typeName":"keyword","multiple":true,"typeClass":"compound","value":[{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Red cells"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Hereditary anemia"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Iron overload"}}]},{"typeName":"notesText","multiple":false,"typeClass":"primitive","value":"Metadata are included in the repository.\nPlease send a request to the Data Access Committee for access to the full data 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