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If you use this dataset in a publication, please cite the dataset, and include the following in the citation: author; year; dataset title; dataset DOI; datase version; repository.","disclaimer":"It is expressly understood that UMC Utrecht does not make any warranties regarding the data and specifically does not warrant or guarantee that the data will be accurate, be merchantable or useful for any particular purpose. Use of the data is at your own risk. UMC Utrecht cannot and shall not be held liable for any claims or damages by you or any third party, in connection with or as a result of the use of data by you. ","termsOfAccess":"By downloading or otherwise accessing the materials, the downloader represents his/her acceptance of the Terms of Use. ","fileAccessRequest":false,"metadataBlocks":{"citation":{"displayName":"Citation Metadata","name":"citation","fields":[{"typeName":"title","multiple":false,"typeClass":"primitive","value":"Inflammation-Induced Mitochondrial and Metabolic Disturbances in Sensory Neurons Control the Switch from Acute to Chronic Pain"},{"typeName":"author","multiple":true,"typeClass":"compound","value":[{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Hanneke LDM Willemen"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"UMC Utrecht"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0000-0001-6132-9449"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Patricia Silva Santos Ribeiro"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"UMC Utrecht"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Melissa Broeks"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"UMC Utrecht"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Nils Meijer"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"UMC Utrecht"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Sabine Versteeg"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"UMC Utrecht"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Annefien Tiggeler"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"UMC Utrecht"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Teun P de Boer"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"UMC Utrecht"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Jedrek Malecki"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Oslo University"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Pal Falnes"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Oslo University"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Judith Jans"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"UMC Utrecht"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Niels Eijkelkamp"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"UMC Utrecht"}}]},{"typeName":"datasetContact","multiple":true,"typeClass":"compound","value":[{"datasetContactName":{"typeName":"datasetContactName","multiple":false,"typeClass":"primitive","value":"data management/Jaap van Minnen"},"datasetContactAffiliation":{"typeName":"datasetContactAffiliation","multiple":false,"typeClass":"primitive","value":"UMC Utrecht"}},{"datasetContactName":{"typeName":"datasetContactName","multiple":false,"typeClass":"primitive","value":"Hanneke LDM Willemen"},"datasetContactAffiliation":{"typeName":"datasetContactAffiliation","multiple":false,"typeClass":"primitive","value":"UMC Utrecht"}}]},{"typeName":"dsDescription","multiple":true,"typeClass":"compound","value":[{"dsDescriptionValue":{"typeName":"dsDescriptionValue","multiple":false,"typeClass":"primitive","value":"Pain often persists in patients with an inflammatory disease, even when inflammation has subsided. The molecular mechanisms leading to this failure in pain resolution and the transition to chronic pain are poorly understood. Mitochondrial dysfunction in sensory neurons links to chronic pain, but its role in resolution of inflammatory pain is unclear. \nTransient inflammation causes neuronal plasticity, called hyperalgesic priming, which impairs resolution of pain induced by a subsequent inflammatory stimulus. We identify that hyperalgesic priming in mice increases the expression of a mitochondrial protein (ATPSc-KMT) and causes mitochondrial and metabolic disturbances in sensory neurons. Inhibition of mitochondrial respiration, knockdown of ATPSCKMT expression or supplementation of the affected metabolite, is sufficient to restore resolution of inflammatory pain and prevent chronic pain development. Thus, inflammation-induced mitochondrial-dependent disturbances in sensory neurons predispose to a failure in resolution of inflammatory pain and development of chronic pain.\n\nOn dataverse we publish our obtained metabomics data, supporting figure 2 and 4 of the manuscript."},"dsDescriptionDate":{"typeName":"dsDescriptionDate","multiple":false,"typeClass":"primitive","value":"2023-09-26"}}]},{"typeName":"subject","multiple":true,"typeClass":"controlledVocabulary","value":["Medicine, Health and Life Sciences"]},{"typeName":"keyword","multiple":true,"typeClass":"compound","value":[{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Mitochondria, metabolism, redox, sensory neurons, inflammation, pain."}}]},{"typeName":"depositor","multiple":false,"typeClass":"primitive","value":"Willemen, Hanneke"},{"typeName":"dateOfDeposit","multiple":false,"typeClass":"primitive","value":"2023-09-26"}]},"dansDataVaultMetadata":{"displayName":"Data Vault Metadata","name":"dansDataVaultMetadata","fields":[{"typeName":"dansDataversePid","multiple":false,"typeClass":"primitive","value":"doi:10.34894/MRMGNW"},{"typeName":"dansDataversePidVersion","multiple":false,"typeClass":"primitive","value":"1.0"},{"typeName":"dansBagId","multiple":false,"typeClass":"primitive","value":"urn:uuid:4f5de27c-d5d4-4fa4-aae4-356f4b5a4b38"},{"typeName":"dansNbn","multiple":false,"typeClass":"primitive","value":"urn:nbn:nl:ui:13-45e0f39c-2316-451e-9b5e-9279ed311c6b"}]}},"files":[{"description":"DI-HRMS metabolomics screen in HAP1 cells (H) and N2A cells (N).\nWT = normal cells with endogenous ATPSc-KMT expression\nKO = knockout for ATPSc-KMT \nKO + WT = knockout for ATPSc-KMT, but reconstituted with wildtype ATPSc-KMT\nKO + KO = knockout for ATPSc-KMT, but reconstituted with catalytical inactive ATPSc-KMT (E117A)","label":"2019_001_N2A_HAP1_EXC.xlsx","restricted":false,"version":1,"datasetVersionId":25364,"dataFile":{"id":382031,"persistentId":"","filename":"2019_001_N2A_HAP1_EXC.xlsx","contentType":"application/vnd.openxmlformats-officedocument.spreadsheetml.sheet","friendlyType":"MS Excel Spreadsheet","filesize":1820400,"description":"DI-HRMS metabolomics screen in HAP1 cells (H) and N2A cells (N).\nWT = normal cells with endogenous ATPSc-KMT expression\nKO = knockout for ATPSc-KMT \nKO + WT = knockout for ATPSc-KMT, but reconstituted with wildtype ATPSc-KMT\nKO + KO = knockout for ATPSc-KMT, but reconstituted with catalytical inactive ATPSc-KMT (E117A)","storageIdentifier":"surf://store:18ad13a5e70-ba65b8610e71","rootDataFileId":-1,"checksum":{"type":"SHA-1","value":"4f65210a5281556720ff54d6b0f6989d68840db0"},"tabularData":false,"creationDate":"2023-09-26","publicationDate":"2023-09-28","lastUpdateTime":"2023-09-28T12:39:04Z","fileAccessRequest":false}},{"description":"samples 13-16: day 0 after carrageenan\nsamples 17-20: day 1 after carrageenan\nsamples 21-24: day 7 after carrageenan ","label":"Res_2021-05-12-testHA_Run50x.xlsx","restricted":false,"version":1,"datasetVersionId":25364,"dataFile":{"id":382042,"persistentId":"","filename":"Res_2021-05-12-testHA_Run50x.xlsx","contentType":"application/vnd.openxmlformats-officedocument.spreadsheetml.sheet","friendlyType":"MS Excel Spreadsheet","filesize":1383789,"description":"samples 13-16: day 0 after carrageenan\nsamples 17-20: day 1 after carrageenan\nsamples 21-24: day 7 after carrageenan ","storageIdentifier":"surf://store:18ad14976a9-8c04a40d86e4","rootDataFileId":-1,"checksum":{"type":"SHA-1","value":"cecfd34290bd9f58da7a8f94627011b4850d14ff"},"tabularData":false,"creationDate":"2023-09-26","publicationDate":"2023-09-28","lastUpdateTime":"2023-09-28T12:39:04Z","fileAccessRequest":false}}]}}}