{"status":"OK","data":{"id":552871,"identifier":"L3MEYZ","persistentUrl":"https://doi.org/10.34894/L3MEYZ","protocol":"doi","authority":"10.34894","separator":"/","publisher":"DataverseNL","publicationDate":"2026-01-05","storageIdentifier":"surf://10.34894/L3MEYZ","effectiveDatasetFileCountLimit":10000,"datasetFileUploadsAvailable":10000,"datasetType":"dataset","locks":[],"latestVersion":{"id":31646,"datasetId":552871,"datasetPersistentId":"doi:10.34894/L3MEYZ","datasetType":"dataset","storageIdentifier":"surf://10.34894/L3MEYZ","versionNumber":1,"internalVersionNumber":15,"versionMinorNumber":0,"versionState":"RELEASED","latestVersionPublishingState":"RELEASED","deaccessionLink":"","productionDate":"2024-10-07","lastUpdateTime":"2026-01-05T10:05:28Z","releaseTime":"2026-01-05T10:05:28Z","createTime":"2025-09-26T16:27:39Z","publicationDate":"2026-01-05","citationDate":"2026-01-05","effectiveDatasetFileCountLimit":10000,"datasetFileUploadsAvailable":10000,"license":{"name":"CC-BY-4.0","uri":"http://creativecommons.org/licenses/by/4.0","iconUri":"https://i.creativecommons.org/l/by/4.0/88x31.png"},"fileAccessRequest":true,"metadataBlocks":{"citation":{"displayName":"Citation Metadata","name":"citation","fields":[{"typeName":"title","multiple":false,"typeClass":"primitive","value":"Complete responders in patients with HER2-positive metastatic breast cancer: a real-world SONABRE study"},{"typeName":"author","multiple":true,"typeClass":"compound","value":[{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Ding, Nan"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"https://ror.org/02jz4aj89","expandedvalue":{"scheme":"http://www.grid.ac/ontology/","termName":"Maastricht University","@type":"https://schema.org/Organization"}},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0009-0004-5719-0738"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Visserman, Renee"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"https://ror.org/02jz4aj89","expandedvalue":{"scheme":"http://www.grid.ac/ontology/","termName":"Maastricht University","@type":"https://schema.org/Organization"}},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0009-0001-6279-9917"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Geurts, Sandra"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"https://ror.org/02d9ce178","expandedvalue":{"scheme":"http://www.grid.ac/ontology/","termName":"Maastricht University Medical Centre","@type":"https://schema.org/Organization"}},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0000-0002-4265-9968"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Tol, Jolien"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"https://ror.org/04rr42t68","expandedvalue":{"scheme":"http://www.grid.ac/ontology/","termName":"Jeroen Bosch Ziekenhuis","@type":"https://schema.org/Organization"}},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0000-0001-7805-2650"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Vriens, Birgit"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"https://ror.org/01qavk531","expandedvalue":{"scheme":"http://www.grid.ac/ontology/","termName":"Catharina Ziekenhuis","@type":"https://schema.org/Organization"}},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0000-0002-6782-6291"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Aaldering, Kirsten"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"https://ror.org/053njym08","expandedvalue":{"scheme":"http://www.grid.ac/ontology/","termName":"Laurentius Ziekenhuis","@type":"https://schema.org/Organization"}},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0000-0002-9590-1922"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Boon, Eline"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"https://ror.org/02kjpb485","expandedvalue":{"scheme":"http://www.grid.ac/ontology/","termName":"VieCuri Medisch Centrum","@type":"https://schema.org/Organization"}},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0000-0002-9768-2911"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Dercksen, Marcus"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"https://ror.org/02x6rcb77","expandedvalue":{"scheme":"http://www.grid.ac/ontology/","termName":"Máxima Medisch Centrum","@type":"https://schema.org/Organization"}},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0000-0002-3441-1399"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"van der Berkmortel, Franchette"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"https://ror.org/03bfc4534","expandedvalue":{"scheme":"http://www.grid.ac/ontology/","termName":"Zuyderland Medisch Centrum","@type":"https://schema.org/Organization"}},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0000-0002-2400-0692"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Pepels, Manon"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"https://ror.org/01q750e89","expandedvalue":{"scheme":"http://www.grid.ac/ontology/","termName":"Elkerliek Ziekenhuis","@type":"https://schema.org/Organization"}}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Peters, Natascha"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"https://ror.org/01a91k946","expandedvalue":{"scheme":"http://www.grid.ac/ontology/","termName":"St.Jans Gasthuis Weert","@type":"https://schema.org/Organization"}}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Heijns, Joan"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"https://ror.org/01g21pa45","expandedvalue":{"scheme":"http://www.grid.ac/ontology/","termName":"Amphia Ziekenhuis","@type":"https://schema.org/Organization"}},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0009-0006-0328-9753"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"van de Winkel, Linda"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"https://ror.org/04y89nz36","expandedvalue":{"scheme":"http://www.grid.ac/ontology/","termName":"St. Anna Ziekenhuis","@type":"https://schema.org/Organization"}}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"de Fallois, Aude"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"https://ror.org/02d9ce178","expandedvalue":{"scheme":"http://www.grid.ac/ontology/","termName":"Maastricht University Medical Centre","@type":"https://schema.org/Organization"}}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Tjan-Heijnen, Vivianne"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"https://ror.org/02d9ce178","expandedvalue":{"scheme":"http://www.grid.ac/ontology/","termName":"Maastricht University Medical Centre","@type":"https://schema.org/Organization"}},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0000-0002-3935-7440"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"de Boer, Maaike"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"https://ror.org/02d9ce178","expandedvalue":{"scheme":"http://www.grid.ac/ontology/","termName":"Maastricht University Medical Centre","@type":"https://schema.org/Organization"}},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0000-0002-0835-8651"}}]},{"typeName":"datasetContact","multiple":true,"typeClass":"compound","value":[{"datasetContactName":{"typeName":"datasetContactName","multiple":false,"typeClass":"primitive","value":"Geurts, Sandra"},"datasetContactAffiliation":{"typeName":"datasetContactAffiliation","multiple":false,"typeClass":"primitive","value":"Maastricht University Medical Centre"}}]},{"typeName":"dsDescription","multiple":true,"typeClass":"compound","value":[{"dsDescriptionValue":{"typeName":"dsDescriptionValue","multiple":false,"typeClass":"primitive","value":"Background: We aimed to describe real-world complete response (CR) rates, predictors of CR, and survival outcomes in patients treated with first-line pertuzumab, trastuzumab, and chemotherapy for HER2-positive (HER2+) metastatic breast cancer (MBC).\n\nMethods: Patients with HER2+ MBC who started first-line pertuzumab, trastuzumab, and chemotherapy in 2013-2021 were selected from the SONABRE Registry (NCT-03577197), involving eleven Dutch hospitals. CR was defined as no evidence of disease on imaging during first-line systemic therapy with or without local therapy (surgery and/or radiotherapy). Multivariable logistic regression was used to identify predictors for CR. Progression-free survival (PFS) and overall survival (OS) from the start of first-line pertuzumab, trastuzumab, and chemotherapy were computed with the Kaplan-Meier method.\n\nResults: We included 244 patients treated with first-line pertuzumab, trastuzumab, and chemotherapy, with a median follow-up duration of 71 months (interquartile range: 60-82 months). A CR during first-line systemic therapy was reached in 63 patients (26 %). Patients younger than 65 years (odds ratio (OR) = 5.24, 95 %CI:1.49-18.44, p = 0.01), those with de Novo MBC (OR = 2.48, 95 %CI:1.24-4.93, p = 0.01), or those with a single metastatic site (OR = 3.81, 95 %CI:1.83-7.96, p < 0.001) were more likely to reach CR than their counterparts. The 5-year PFS and OS rates were, respectively, 63 % (95 %CI:48 %-75 %) and 85 % (95 %CI:72 %-92 %) in patients with a CR and 10 % (95 %CI:6 %-16 %) and 36 % (95 %CI:28 %-44 %) in patients without a CR.\n\nConclusions: In the real world, one in four patients treated with first-line pertuzumab, trastuzumab, chemotherapy, with or without local therapy, reached CR. Two third of patients with a CR were still free of progression after five years."},"dsDescriptionDate":{"typeName":"dsDescriptionDate","multiple":false,"typeClass":"primitive","value":"2025-11-19"}}]},{"typeName":"subject","multiple":true,"typeClass":"controlledVocabulary","value":["Medicine, Health and Life Sciences"]},{"typeName":"keyword","multiple":true,"typeClass":"compound","value":[{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Breast Neoplasms"},"keywordTermURI":{"typeName":"keywordTermURI","multiple":false,"typeClass":"primitive","value":"https://meshb.nlm.nih.gov/record/ui?ui=D001943"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Disease Progression"},"keywordTermURI":{"typeName":"keywordTermURI","multiple":false,"typeClass":"primitive","value":"https://meshb.nlm.nih.gov/record/ui?ui=D018450"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"HER-2 Gene"},"keywordVocabulary":{"typeName":"keywordVocabulary","multiple":false,"typeClass":"primitive","value":"Genes, erbB-2 (MeSH)"},"keywordVocabularyURI":{"typeName":"keywordVocabularyURI","multiple":false,"typeClass":"primitive","value":"https://meshb.nlm.nih.gov/record/ui?ui=D018734"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Peruzumab"},"keywordTermURI":{"typeName":"keywordTermURI","multiple":false,"typeClass":"primitive","value":"https://meshb.nlm.nih.gov/record/ui?ui=C485206"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Survival"},"keywordTermURI":{"typeName":"keywordTermURI","multiple":false,"typeClass":"primitive","value":"https://meshb.nlm.nih.gov/record/ui?ui=D013534"}}]},{"typeName":"publication","multiple":true,"typeClass":"compound","value":[{"publicationRelationType":{"typeName":"publicationRelationType","multiple":false,"typeClass":"controlledVocabulary","value":"References"},"publicationCitation":{"typeName":"publicationCitation","multiple":false,"typeClass":"primitive","value":"Ding N, Visserman R, Geurts SME, Tol J, Vriens BEPJ, Aaldering KNA, Boon E, Dercksen MW, van den Berkmortel F, Pepels MJAE, Peters NAJB, Heijns JB, van de Winkel L, de Fallois AJO, Tjan-Heijnen VCG, de Boer M. Complete responders in patients with HER2-positive metastatic breast cancer: a real-world SONABRE study. Breast. 2025 Sep 23;84:104583. doi: 10.1016/j.breast.2025.104583. Epub ahead of print. PMID: 41014745; PMCID: PMC12510007."},"publicationIDType":{"typeName":"publicationIDType","multiple":false,"typeClass":"controlledVocabulary","value":"doi"},"publicationIDNumber":{"typeName":"publicationIDNumber","multiple":false,"typeClass":"primitive","value":"https://doi.org/10.1016/j.breast.2025.104583"},"publicationURL":{"typeName":"publicationURL","multiple":false,"typeClass":"primitive","value":"https://doi.org/10.1016/j.breast.2025.104583"}}]},{"typeName":"language","multiple":true,"typeClass":"controlledVocabulary","value":["English"]},{"typeName":"producer","multiple":true,"typeClass":"compound","value":[{"producerName":{"typeName":"producerName","multiple":false,"typeClass":"primitive","value":"Maastrcht University Medical Centre"},"producerAbbreviation":{"typeName":"producerAbbreviation","multiple":false,"typeClass":"primitive","value":"MUMC+"}}]},{"typeName":"productionDate","multiple":false,"typeClass":"primitive","value":"2024-10-07"},{"typeName":"productionPlace","multiple":true,"typeClass":"primitive","value":["Maastricht"]},{"typeName":"grantNumber","multiple":true,"typeClass":"compound","value":[{"grantNumberAgency":{"typeName":"grantNumberAgency","multiple":false,"typeClass":"primitive","value":"Netherlands Organization for Health Research and Development (ZonMw)"},"grantNumberValue":{"typeName":"grantNumberValue","multiple":false,"typeClass":"primitive","value":"80–82500-98–8003, 10140312310018"}},{"grantNumberAgency":{"typeName":"grantNumberAgency","multiple":false,"typeClass":"primitive","value":"Novartis BV"}},{"grantNumberAgency":{"typeName":"grantNumberAgency","multiple":false,"typeClass":"primitive","value":"Roche"}},{"grantNumberAgency":{"typeName":"grantNumberAgency","multiple":false,"typeClass":"primitive","value":"Pfizer"}},{"grantNumberAgency":{"typeName":"grantNumberAgency","multiple":false,"typeClass":"primitive","value":"Eli Lilly & Co"}},{"grantNumberAgency":{"typeName":"grantNumberAgency","multiple":false,"typeClass":"primitive","value":"Gilead"}},{"grantNumberAgency":{"typeName":"grantNumberAgency","multiple":false,"typeClass":"primitive","value":"AstraZeneca"}}]},{"typeName":"depositor","multiple":false,"typeClass":"primitive","value":"Visserman, Renée"},{"typeName":"dateOfDeposit","multiple":false,"typeClass":"primitive","value":"2025-11-19"},{"typeName":"timePeriodCovered","multiple":true,"typeClass":"compound","value":[{"timePeriodCoveredStart":{"typeName":"timePeriodCoveredStart","multiple":false,"typeClass":"primitive","value":"2013"},"timePeriodCoveredEnd":{"typeName":"timePeriodCoveredEnd","multiple":false,"typeClass":"primitive","value":"2021"}}]},{"typeName":"dateOfCollection","multiple":true,"typeClass":"compound","value":[{"dateOfCollectionStart":{"typeName":"dateOfCollectionStart","multiple":false,"typeClass":"primitive","value":"2007-01-01"},"dateOfCollectionEnd":{"typeName":"dateOfCollectionEnd","multiple":false,"typeClass":"primitive","value":"2024-10-07"}}]}]},"dansDataVaultMetadata":{"displayName":"Data Vault Metadata","name":"dansDataVaultMetadata","fields":[{"typeName":"dansDataversePid","multiple":false,"typeClass":"primitive","value":"doi:10.34894/L3MEYZ"},{"typeName":"dansDataversePidVersion","multiple":false,"typeClass":"primitive","value":"1.0"},{"typeName":"dansBagId","multiple":false,"typeClass":"primitive","value":"urn:uuid:85a6b8da-1bf7-42a8-a6be-aa6c9baf1212"},{"typeName":"dansNbn","multiple":false,"typeClass":"primitive","value":"urn:nbn:nl:ui:13-fa6574f0-82e8-438f-948f-8b1e0c7b21fb"}]}},"files":[]}}}