{"status":"OK","data":{"id":13391,"identifier":"KN3EZU","persistentUrl":"https://doi.org/10.34894/KN3EZU","protocol":"doi","authority":"10.34894","separator":"/","publisher":"DataverseNL","publicationDate":"2019-03-05","storageIdentifier":"surf://10411/9QCQOC","effectiveDatasetFileCountLimit":10000,"datasetFileUploadsAvailable":9997,"datasetType":"dataset","locks":[],"latestVersion":{"id":1485,"datasetId":13391,"datasetPersistentId":"doi:10.34894/KN3EZU","datasetType":"dataset","storageIdentifier":"surf://10411/9QCQOC","versionNumber":1,"internalVersionNumber":6,"versionMinorNumber":0,"versionState":"RELEASED","latestVersionPublishingState":"RELEASED","deaccessionLink":"","lastUpdateTime":"2019-03-05T22:44:47Z","releaseTime":"2019-03-05T22:44:47Z","createTime":"2019-01-25T13:08:51Z","alternativePersistentId":"hdl:10411/9QCQOC","publicationDate":"2019-03-05","citationDate":"2019-03-05","effectiveDatasetFileCountLimit":10000,"datasetFileUploadsAvailable":9997,"license":{"name":"CC0-1.0","uri":"http://creativecommons.org/publicdomain/zero/1.0","iconUri":"https://licensebuttons.net/p/zero/1.0/88x31.png","rightsIdentifier":"CC0-1.0","rightsIdentifierScheme":"SPDX","schemeUri":"https://spdx.org/licenses/","languageCode":"en"},"fileAccessRequest":false,"metadataBlocks":{"citation":{"displayName":"Citation Metadata","name":"citation","fields":[{"typeName":"title","multiple":false,"typeClass":"primitive","value":"Replication Data for: Long-term dietary intervention with low Phe and/or a specific nutrient combination improve certain aspects of brain functioning in Phenylketonuria (PKU)"},{"typeName":"author","multiple":true,"typeClass":"compound","value":[{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Bruinenberg, Vibeke M."},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Groningen Institute of Evolutionary Life Sciences"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"van Vliet, Danique"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"University Medical Center of Groningen"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"van der Goot, Els"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Groningen Institute of Evolutionary Life Sciences"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"de Vries, Minke L."},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Groningen Institute of Evolutionary Life Sciences"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Counotte, Danielle S. "}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Kuhn, Mirjam"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"van Spronsen, Francjan J."},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"University Medical Center of Groningen"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"van der Zee, Eddy A."},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Groningen Institute of Evolutionary Life Sciences"}}]},{"typeName":"datasetContact","multiple":true,"typeClass":"compound","value":[{"datasetContactName":{"typeName":"datasetContactName","multiple":false,"typeClass":"primitive","value":"van der Zee, Eddy A."},"datasetContactAffiliation":{"typeName":"datasetContactAffiliation","multiple":false,"typeClass":"primitive","value":"Groningen Institute of Evolutionary Life Sciences"}}]},{"typeName":"dsDescription","multiple":true,"typeClass":"compound","value":[{"dsDescriptionValue":{"typeName":"dsDescriptionValue","multiple":false,"typeClass":"primitive","value":"<p>48 Homozygous wild-types (WT, +/+) and 96 PKU BTBRPah2 (-/-) male and female mice started dietary treatment on postnatal day 31 up to 10 months of age in the following six groups: WT control diet (WT C-HP), WT normal diet plus specific nutrient combination (WT SNC-HP), PKU normal diet (PKU C-HP), PKU normal diet plus specific nutrient combination (PKU SNC-HP), PKU low-Phe diet (PKU C-LP), and PKU low-Phe diet plus specific nutrient combination (PKU SNC-LP).</p>\r\n<p>Mice were tested three times (4,7, and 10 months) after treatment initiation during four behavioural tasks: open field (OF), novel object recognition task (NOR), spatial object recognition task (SOR), and balance beam task (BB).</p>\r\n<p>The results are stored in three zipped folders:</p>\r\n<ul>\r\n<li>Measurements.zip: Excel files with the results of the various behavioral tasks at 4, 7 and 10 months of age</li>\r\n<li>StatisticalAnalyses.zip: SPSS files (.sav) of the various behavioral tasks</li>\r\n<li>Neurotransmitters: Results and statistical analysis of the various neurotransmitter levels per mouse</li>\r\n</ul>"},"dsDescriptionDate":{"typeName":"dsDescriptionDate","multiple":false,"typeClass":"primitive","value":"2019-01-25"}}]},{"typeName":"subject","multiple":true,"typeClass":"controlledVocabulary","value":["Medicine, Health and Life Sciences"]},{"typeName":"keyword","multiple":true,"typeClass":"compound","value":[{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Phenylketonuria"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"dietary intervention"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"nutrient combination"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"brain functioning"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"mouse model"}}]},{"typeName":"publication","multiple":true,"typeClass":"compound","value":[{"publicationCitation":{"typeName":"publicationCitation","multiple":false,"typeClass":"primitive","value":"Bruinenberg VM, van Vliet D, van der Goot E, de Vries ML, Counotte DS, Kuhn M, van Spronsen FJ, van der Zee EA (2019): Long-term dietary intervention with low Phe and/or a specific nutrient combination improve certain aspects of brain functioning in Phenylketonuria (PKU). Subm."}}]},{"typeName":"depositor","multiple":false,"typeClass":"primitive","value":"Bakker, Joke"},{"typeName":"dateOfDeposit","multiple":false,"typeClass":"primitive","value":"2019-01-25"}]},"dansDataVaultMetadata":{"displayName":"Data Vault Metadata","name":"dansDataVaultMetadata","fields":[{"typeName":"dansDataversePid","multiple":false,"typeClass":"primitive","value":"doi:10.34894/KN3EZU"},{"typeName":"dansDataversePidVersion","multiple":false,"typeClass":"primitive","value":"1.0"},{"typeName":"dansBagId","multiple":false,"typeClass":"primitive","value":"urn:uuid:761b9baa-09e4-4453-8fd6-b42ed76821f8"},{"typeName":"dansNbn","multiple":false,"typeClass":"primitive","value":"urn:nbn:nl:ui:13-1c82d8c1-40b6-4937-a362-d895893f977f"}]}},"files":[{"description":"This folder contains the Excel files with the results of the various behavioral tasks at 4, 7 and 10 months of age: Balance Beam task (BB: BB_4mo.xlsx, BB_7mo.xlsx, and BB_10mo.xlsx), Novel Object Recognition task (NOR: NOR_4mo.xlsx, NOR_7mo.xlsx, and NOR_10mo.xlsx), Open Field as part of the NOR (OF: Openfield_NOR_4mo.xlsx, Openfield_NOR_7mo.xlsx, and Openfield_NOR_10mo.xlsx), and the Spatial Object Recognition task (SOR: SOR_4mo.xlsx, SOR_7mo.xlsx, and SOR_10mo.xlsx). It also contains the body weights (BW) of the animals during the experiment at Maintenance diet and Growth diet (Bodyweight growthdiet.xlsx and Bodyweight_maintenancediet.xlsx). ","label":"Measurements.zip","restricted":false,"version":1,"datasetVersionId":1485,"dataFile":{"id":13394,"persistentId":"","filename":"Measurements.zip","contentType":"application/zip","friendlyType":"ZIP Archive","filesize":686148,"description":"This folder contains the Excel files with the results of the various behavioral tasks at 4, 7 and 10 months of age: Balance Beam task (BB: BB_4mo.xlsx, BB_7mo.xlsx, and BB_10mo.xlsx), Novel Object Recognition task (NOR: NOR_4mo.xlsx, NOR_7mo.xlsx, and NOR_10mo.xlsx), Open Field as part of the NOR (OF: Openfield_NOR_4mo.xlsx, Openfield_NOR_7mo.xlsx, and Openfield_NOR_10mo.xlsx), and the Spatial Object Recognition task (SOR: SOR_4mo.xlsx, SOR_7mo.xlsx, and SOR_10mo.xlsx). It also contains the body weights (BW) of the animals during the experiment at Maintenance diet and Growth diet (Bodyweight growthdiet.xlsx and Bodyweight_maintenancediet.xlsx). 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It also contains specific (health) information of the mice as an Excel file (Animal_characteristics_final.xlsx).","label":"StatisticalAnalyses.zip","restricted":false,"version":1,"datasetVersionId":1485,"dataFile":{"id":13393,"persistentId":"","filename":"StatisticalAnalyses.zip","contentType":"application/zip","friendlyType":"ZIP Archive","filesize":120043,"description":"This folder contains the SPSS files (.sav) of the various behavioral tasks: Balance Beam task (BB: BB_linear.sav and BB_overall.sav), Novel Object Recognition task (NOR: NOR_Linear.sav and NOR_overall.sav), Open Field (OF: Openfield_linear.sav and Openfield_overall.sav), and the Spatial Object Recognition task (SOR: SOR_Linear.sav and SOR_overall.sav), the body weights (BW) of the animals during the experiment at Maintenance diet and Growth diet (BW and FI_Linear_Maintenance.sav and BW_linear_Growth.sav). 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