{"status":"OK","data":{"id":449,"identifier":"JTVNF2","persistentUrl":"https://doi.org/10.34894/JTVNF2","protocol":"doi","authority":"10.34894","separator":"/","publisher":"DataverseNL","publicationDate":"2015-11-23","storageIdentifier":"surf://10411/20630","effectiveDatasetFileCountLimit":10000,"datasetFileUploadsAvailable":9998,"datasetType":"dataset","locks":[],"latestVersion":{"id":742,"datasetId":449,"datasetPersistentId":"doi:10.34894/JTVNF2","datasetType":"dataset","storageIdentifier":"surf://10411/20630","versionNumber":2,"internalVersionNumber":3,"versionMinorNumber":1,"versionState":"RELEASED","latestVersionPublishingState":"RELEASED","deaccessionLink":"","lastUpdateTime":"2017-03-02T15:29:26Z","releaseTime":"2017-03-02T15:29:26Z","createTime":"2017-03-02T15:29:04Z","alternativePersistentId":"hdl:10411/20630","publicationDate":"2015-11-23","citationDate":"2015-11-23","effectiveDatasetFileCountLimit":10000,"datasetFileUploadsAvailable":9998,"termsOfUse":"This dataset is made available without information on how it can be used. You should communicate with the Contact(s) specified before use.","sizeOfCollection":"113","fileAccessRequest":false,"metadataBlocks":{"citation":{"displayName":"Citation Metadata","name":"citation","fields":[{"typeName":"title","multiple":false,"typeClass":"primitive","value":"Surface-based analyses of anatomical properties of the visual cortex in macular degeneration"},{"typeName":"author","multiple":true,"typeClass":"compound","value":[{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Prins, Doety"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Laboratory of Experimental Ophthalmology, Department of Ophthalmology, University of Groningen, University Medical Center Groningen"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Plank, Tina"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Institute for Experimental Psychology, University of Regensburg, Regensburg, Germany"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Baseler, Heidi A."},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Department of Psychology, University of York, York, United Kingdom and Centre for Neuroscience, Hull-York Medical School, York, United Kingdom"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Gouws, André D."},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Centre for Neuroscience, Hull-York Medical School, York, United Kingdom"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Beer,Anton"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Institute for Experimental Psychology, University of Regensburg, Regensburg, Germany"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Morland, Antony B."},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Department of Psychology, University of York, York, United Kingdom"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Greenlee, Mark W."},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Institute for Experimental Psychology, University of Regensburg, Regensburg, Germany"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Cornelissen, Frans W."},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Laboratory of Experimental Ophthalmology, Department of Ophthalmology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands"}}]},{"typeName":"datasetContact","multiple":true,"typeClass":"compound","value":[{"datasetContactName":{"typeName":"datasetContactName","multiple":false,"typeClass":"primitive","value":"Research Data Office"},"datasetContactAffiliation":{"typeName":"datasetContactAffiliation","multiple":false,"typeClass":"primitive","value":"University of Groningen"}}]},{"typeName":"dsDescription","multiple":true,"typeClass":"compound","value":[{"dsDescriptionValue":{"typeName":"dsDescriptionValue","multiple":false,"typeClass":"primitive","value":"Introduction  Macular degeneration (MD) can cause a central visual field defect. In a previous study, we found volumetric reductions along the entire visual pathways of MD patients, possibly indicating degeneration of inactive neuronal tissue. This may have important implications. In particular, new therapeutic strategies to restore retinal function rely on intact visual pathways and cortex to reestablish visual function. Here we reanalyze the data of our previous study using surface-based morphometry (SBM) rather than voxel-based morphometry (VBM). This can help determine the robustness of the findings and will lead to a better understanding of the nature of neuroanatomical changes associated with MD.   Methods  The metrics of interest were acquired by performing SBM analysis on T1-weighted MRI data acquired from 113 subjects: patients with juvenile MD (JMD; n = 34), patients with age-related MD (AMD; n = 24) and healthy age-matched controls (HC; n = 55).   Results  Relative to age-matched controls, JMD patients showed a thinner cortex, a smaller cortical surface area and a lower grey matter volume in V1 and V2, while AMD patients showed thinning of the cortex in V2. Neither patient group showed a significant difference in mean curvature of the visual cortex.   Discussion  The thinner cortex, smaller surface area and lower grey matter volume in the visual cortex of JMD patients are consistent with our previous results showing a volumetric reduction in their visual cortex. Finding comparable results using two rather different analysis techniques suggests the presence of marked cortical degeneration in the JMD patients. In the AMD patients, we found a thinner cortex in V2 but not in V1. In contrast to our previous VBM analysis, SBM revealed no volumetric reductions of the visual cortex. This suggests that the cortical changes in AMD patients are relatively subtle, as they apparently can be missed by one of the methods."},"dsDescriptionDate":{"typeName":"dsDescriptionDate","multiple":false,"typeClass":"primitive","value":"2015-11-23"}}]},{"typeName":"subject","multiple":true,"typeClass":"controlledVocabulary","value":["Medicine, Health and Life Sciences"]},{"typeName":"keyword","multiple":true,"typeClass":"compound","value":[{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Macular Degeneration"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Visual Cortex"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Neuro-imaging"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"magnetic resonance imaging"}}]},{"typeName":"topicClassification","multiple":true,"typeClass":"compound","value":[{"topicClassValue":{"typeName":"topicClassValue","multiple":false,"typeClass":"primitive","value":"Ophthalmology"},"topicClassVocab":{"typeName":"topicClassVocab","multiple":false,"typeClass":"primitive","value":"LoC"}}]},{"typeName":"producer","multiple":true,"typeClass":"compound","value":[{"producerName":{"typeName":"producerName","multiple":false,"typeClass":"primitive","value":"University of Groningen"},"producerAbbreviation":{"typeName":"producerAbbreviation","multiple":false,"typeClass":"primitive","value":"UG"},"producerURL":{"typeName":"producerURL","multiple":false,"typeClass":"primitive","value":"http://www.rug.nl"}},{"producerName":{"typeName":"producerName","multiple":false,"typeClass":"primitive","value":"University Medical Center Groningen "},"producerAbbreviation":{"typeName":"producerAbbreviation","multiple":false,"typeClass":"primitive","value":"UMCG"},"producerURL":{"typeName":"producerURL","multiple":false,"typeClass":"primitive","value":"http://www.umcg.nl"}},{"producerName":{"typeName":"producerName","multiple":false,"typeClass":"primitive","value":"University of Regensburg"},"producerURL":{"typeName":"producerURL","multiple":false,"typeClass":"primitive","value":"http://www.uni-regensburg.de/index.html.en"}},{"producerName":{"typeName":"producerName","multiple":false,"typeClass":"primitive","value":"University of York"},"producerURL":{"typeName":"producerURL","multiple":false,"typeClass":"primitive","value":"http://www.york.ac.uk/"}},{"producerName":{"typeName":"producerName","multiple":false,"typeClass":"primitive","value":"Hull-York Medical School York"},"producerURL":{"typeName":"producerURL","multiple":false,"typeClass":"primitive","value":"http://www.hyms.ac.uk/"}}]},{"typeName":"distributor","multiple":true,"typeClass":"compound","value":[{"distributorName":{"typeName":"distributorName","multiple":false,"typeClass":"primitive","value":"University of Groningen"},"distributorAbbreviation":{"typeName":"distributorAbbreviation","multiple":false,"typeClass":"primitive","value":"UoG"},"distributorURL":{"typeName":"distributorURL","multiple":false,"typeClass":"primitive","value":"http://www.rug.nl"}},{"distributorName":{"typeName":"distributorName","multiple":false,"typeClass":"primitive","value":"University Medical Center Groningen"},"distributorAbbreviation":{"typeName":"distributorAbbreviation","multiple":false,"typeClass":"primitive","value":"UMCG"},"distributorURL":{"typeName":"distributorURL","multiple":false,"typeClass":"primitive","value":"http://www.umcg.nl"}}]},{"typeName":"dateOfDeposit","multiple":false,"typeClass":"primitive","value":"2015-11-23"},{"typeName":"kindOfData","multiple":true,"typeClass":"primitive","value":["MRI scans"]},{"typeName":"relatedDatasets","multiple":true,"typeClass":"primitive","value":["Hernowo AT, Prins D, Baseler HA, Plank T, Gouws AD, et al. 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