{"status":"OK","data":{"id":360205,"identifier":"IXQ5VP","persistentUrl":"https://doi.org/10.34894/IXQ5VP","protocol":"doi","authority":"10.34894","separator":"/","publisher":"DataverseNL","publicationDate":"2023-05-02","storageIdentifier":"surf://10.34894/IXQ5VP","effectiveDatasetFileCountLimit":10000,"datasetFileUploadsAvailable":9996,"datasetType":"dataset","locks":[],"latestVersion":{"id":25009,"datasetId":360205,"datasetPersistentId":"doi:10.34894/IXQ5VP","datasetType":"dataset","storageIdentifier":"surf://10.34894/IXQ5VP","versionNumber":1,"internalVersionNumber":7,"versionMinorNumber":0,"versionState":"RELEASED","latestVersionPublishingState":"DRAFT","deaccessionLink":"","lastUpdateTime":"2023-05-02T10:48:07Z","releaseTime":"2023-05-02T10:48:07Z","createTime":"2023-05-02T10:44:35Z","publicationDate":"2023-05-02","citationDate":"2023-05-02","effectiveDatasetFileCountLimit":10000,"datasetFileUploadsAvailable":9996,"termsOfUse":"The standard Data Sharing Agreement (DSA) of the UMC Utrecht must be signed without adjustments. This DSA is in compliance with Dutch law. No costs are involved.","confidentialityDeclaration":"no","specialPermissions":"To obtain access to the data, a <a href=\"https://www.umcutrecht.nl/en/data-request-form-umc-utrecht\">request form</a> has to be completed. In addition to a completed request form, a  Data Sharing Agreement (DSA) in line with GDPR regulations and/or a Research Collaboration Agreement (RCA) should be signed before data is shared. Only data requests in line with the Terms of Use will be taken into consideration. ","restrictions":"See Data Sharing Agreement.","citationRequirements":"See Data Sharing Agreement.","conditions":"To access and use the dataset please read the Terms of Use and the Terms of Access.","disclaimer":"See Data Sharing Agreement.","termsOfAccess":"The data is not available for download directly via DataverseNL. Data is available on request by completing the <a href=\"https://www.umcutrecht.nl/en/data-request-form-umc-utrecht\">request form</a>. Only data requests in line with the Terms of Use will be taken into consideration. In addition to a completed request form, the Data Sharing Agreement (DSA) in line with GDPR regulations and/or the Research Collaboration Agreement (RCA) should be signed before data is shared. If a data request is approved, the data will be delivered in a safe and secure manner. By signing the DSA and/or RCA and accessing the Materials, the recipient represents his/her acceptance of the Terms of Use.  ","availabilityStatus":"The data is not available for download directly via DataverseNL but is available on request if the request is compliant with the Terms of Access. ","contactForAccess":"Please fill out the <a href=\"https://www.umcutrecht.nl/en/data-request-form-umc-utrecht\">request form</a>.","fileAccessRequest":true,"metadataBlocks":{"citation":{"displayName":"Citation Metadata","name":"citation","fields":[{"typeName":"title","multiple":false,"typeClass":"primitive","value":"Beneficial effects of intra-gastric balloon with lifestyle modification on overweight/obese subtype of metabolic dysfunction-associated fatty liver disease"},{"typeName":"author","multiple":true,"typeClass":"compound","value":[{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"van Dijk, Anne, UMC Utrecht"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"UMC Utrecht"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"}}]},{"typeName":"datasetContact","multiple":true,"typeClass":"compound","value":[{"datasetContactName":{"typeName":"datasetContactName","multiple":false,"typeClass":"primitive","value":"data management"},"datasetContactAffiliation":{"typeName":"datasetContactAffiliation","multiple":false,"typeClass":"primitive","value":"UMC Utrecht"}},{"datasetContactName":{"typeName":"datasetContactName","multiple":false,"typeClass":"primitive","value":"van Erpecum, Karel, UMC Utrecht"},"datasetContactAffiliation":{"typeName":"datasetContactAffiliation","multiple":false,"typeClass":"primitive","value":"UMC Utrecht"}},{"datasetContactName":{"typeName":"datasetContactName","multiple":false,"typeClass":"primitive","value":"van Dijk, Anne, UMC Utrecht"},"datasetContactAffiliation":{"typeName":"datasetContactAffiliation","multiple":false,"typeClass":"primitive","value":"UMC Utrecht"}}]},{"typeName":"dsDescription","multiple":true,"typeClass":"compound","value":[{"dsDescriptionValue":{"typeName":"dsDescriptionValue","multiple":false,"typeClass":"primitive","value":"Background: Data on beneficial effects of intra-gastric balloon (IGB) on metabolic dysfunction-associated fatty liver disease (MAFLD) are scarce, and mainly obtained in tertiary care patients with comorbidities. Methods: In this prospective cohort study, patients referred to an obesity clinic were treated with lifestyle modification with or without (based on patient preference) 6 months IGB. Fibrosis and steatosis were assessed with Fibroscan® at baseline, and in case of initial significant or advanced fibrosis or severe steatosis 6 months later. Results: 100 patients were included, largely without comorbidity. At baseline, advanced chronic liver disease (≥F3) was present in 11% and severe steatosis in 46%. IGB was placed in 59% and only lifestyle modification initiated in 41%. Baseline characteristics did not differ between both groups. At 6 months, 29 of 50 participants qualifying for repeated evaluation had a second Fibroscan® (19 IGB, 10 lifestyle modification only, without differences in baseline characteristics between both groups). In the IGB group, BMI decreased significantly more (P<0.001) than in the lifestyle modification only group. Liver stiffness decreased markedly in the IGB group (median: from 6.0 to 4.9 kPa, p=0.005), which was not the case in the lifestyle modification only group (median: from 5.5 to 6.9 kPa, p=0,477). Steatosis improved in both groups, (IGB: controlled attenuation parameter values from 328±34 to 272±62 dB/m, P=0.006: lifestyle modification only: from 344±33 to 305±43 dB/m: P=0.006). Conclusions: Prevalence of MAFLD is high in obese patients without comorbidity. Both steatosis and fibrosis improve after 6 months intra-gastric balloon combined with lifestyle modification."}}]},{"typeName":"subject","multiple":true,"typeClass":"controlledVocabulary","value":["Medicine, Health and Life Sciences"]},{"typeName":"keyword","multiple":true,"typeClass":"compound","value":[{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"metabolic dysfunction-associated fatty liver disease"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"lifestyle modification"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"intra-gastric balloon"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"obese"}}]},{"typeName":"depositor","multiple":false,"typeClass":"primitive","value":"van Dijk, Anne"},{"typeName":"dateOfDeposit","multiple":false,"typeClass":"primitive","value":"2023-05-02"}]},"dansDataVaultMetadata":{"displayName":"Data Vault Metadata","name":"dansDataVaultMetadata","fields":[{"typeName":"dansDataversePid","multiple":false,"typeClass":"primitive","value":"doi:10.34894/IXQ5VP"},{"typeName":"dansDataversePidVersion","multiple":false,"typeClass":"primitive","value":"1.0"},{"typeName":"dansBagId","multiple":false,"typeClass":"primitive","value":"urn:uuid:5946ca99-1219-41d4-8279-bf31d94d9ab0"},{"typeName":"dansNbn","multiple":false,"typeClass":"primitive","value":"urn:nbn:nl:ui:13-d84daa19-ab5f-4370-9e2a-ff7087f08a4f"}]}},"files":[{"label":"2023_IEM_AD_1st.sav","restricted":true,"version":1,"datasetVersionId":25009,"dataFile":{"id":360206,"persistentId":"","filename":"2023_IEM_AD_1st.sav","contentType":"application/x-spss-sav","friendlyType":"SPSS Binary","filesize":17228,"storageIdentifier":"surf://store:187dc0d09bc-4358f5525e64","rootDataFileId":-1,"checksum":{"type":"SHA-1","value":"7b9213096944d130c87e2966145fbdd4b0551e8c"},"tabularData":false,"creationDate":"2023-05-02","publicationDate":"2023-05-02","lastUpdateTime":"2023-05-02T10:48:07Z","fileAccessRequest":true}},{"label":"2023_IEM_AD_2nd.sav","restricted":true,"version":1,"datasetVersionId":25009,"dataFile":{"id":360207,"persistentId":"","filename":"2023_IEM_AD_2nd.sav","contentType":"application/x-spss-sav","friendlyType":"SPSS Binary","filesize":7548,"storageIdentifier":"surf://store:187dc0d0a63-767b868c0a8d","rootDataFileId":-1,"checksum":{"type":"SHA-1","value":"a3a67ea496e71b532d272c2a9ba9acce96a6bf38"},"tabularData":false,"creationDate":"2023-05-02","publicationDate":"2023-05-02","lastUpdateTime":"2023-05-02T10:48:07Z","fileAccessRequest":true}},{"label":"2023_IEM_AD_PIF.pdf","restricted":false,"version":1,"datasetVersionId":25009,"dataFile":{"id":360208,"persistentId":"","filename":"2023_IEM_AD_PIF.pdf","contentType":"application/pdf","friendlyType":"Adobe PDF","filesize":165684,"storageIdentifier":"surf://store:187dc0d0b63-8c51b5ac25cc","rootDataFileId":-1,"checksum":{"type":"SHA-1","value":"dd30e24ed5e02c1ca83f7690efffbcb5812461a5"},"tabularData":false,"creationDate":"2023-05-02","publicationDate":"2023-05-02","lastUpdateTime":"2023-05-02T10:48:07Z","fileAccessRequest":true}},{"label":"2023_IEM_AD_Syntax.sps","restricted":false,"version":1,"datasetVersionId":25009,"dataFile":{"id":360209,"persistentId":"","filename":"2023_IEM_AD_Syntax.sps","contentType":"application/x-spss-syntax","friendlyType":"SPSS Syntax","filesize":122648,"storageIdentifier":"surf://store:187dc0d0c35-d8d47a0e9661","rootDataFileId":-1,"checksum":{"type":"SHA-1","value":"2947d85f4ecf4dfbbcccb1443009297793827df7"},"tabularData":false,"creationDate":"2023-05-02","publicationDate":"2023-05-02","lastUpdateTime":"2023-05-02T10:48:07Z","fileAccessRequest":true}}]}}}