{"status":"OK","data":{"id":483599,"identifier":"GTKDH6","persistentUrl":"https://doi.org/10.34894/GTKDH6","protocol":"doi","authority":"10.34894","separator":"/","publisher":"DataverseNL","publicationDate":"2025-07-14","storageIdentifier":"surf://10.34894/GTKDH6","effectiveDatasetFileCountLimit":10000,"datasetFileUploadsAvailable":9999,"datasetType":"dataset","locks":[],"latestVersion":{"id":30601,"datasetId":483599,"datasetPersistentId":"doi:10.34894/GTKDH6","datasetType":"dataset","storageIdentifier":"surf://10.34894/GTKDH6","versionNumber":1,"internalVersionNumber":25,"versionMinorNumber":0,"versionState":"RELEASED","latestVersionPublishingState":"RELEASED","deaccessionLink":"","distributionDate":"2025-06-22","productionDate":"2012-10-01","lastUpdateTime":"2025-07-14T09:01:17Z","releaseTime":"2025-07-14T09:01:17Z","createTime":"2025-05-14T13:59:20Z","publicationDate":"2025-07-14","citationDate":"2025-07-14","effectiveDatasetFileCountLimit":10000,"datasetFileUploadsAvailable":9999,"license":{"name":"CC-BY-4.0","uri":"http://creativecommons.org/licenses/by/4.0","iconUri":"https://i.creativecommons.org/l/by/4.0/88x31.png"},"fileAccessRequest":true,"metadataBlocks":{"citation":{"displayName":"Citation Metadata","name":"citation","fields":[{"typeName":"title","multiple":false,"typeClass":"primitive","value":"Dataset: Anesthesia and Acute Phase Response in Living Kidney Donors"},{"typeName":"author","multiple":true,"typeClass":"compound","value":[{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Nieuwenhuijs-Moeke, Gertrude"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"https://ror.org/03cv38k47","expandedvalue":{"scheme":"http://www.grid.ac/ontology/","termName":"University Medical Center Groningen","@type":"https://schema.org/Organization"}},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"https://orcid.org/0000-0001-9874-2632"}}]},{"typeName":"datasetContact","multiple":true,"typeClass":"compound","value":[{"datasetContactName":{"typeName":"datasetContactName","multiple":false,"typeClass":"primitive","value":"Groningen Digital Competence Centre"},"datasetContactAffiliation":{"typeName":"datasetContactAffiliation","multiple":false,"typeClass":"primitive","value":"University of Groningen"}}]},{"typeName":"dsDescription","multiple":true,"typeClass":"compound","value":[{"dsDescriptionValue":{"typeName":"dsDescriptionValue","multiple":false,"typeClass":"primitive","value":"A Surgical trauma elicits a complex inflammatory stress response, contributing to postoperative morbidity and recovery variability. This response is influenced by patient-specific factors and surgical and anesthetic techniques. <br>\nTo isolate the impact of anesthesia on the acute phase response, we investigated plasma proteomic changes in a uniquely homogeneous cohort of healthy, living kidney donors (n = 36; propofol = 19; sevoflurane = 17) undergoing laparoscopic donor nephrectomy. Proteomic profiling of plasma samples collected preoperatively and at 2 and 24 h postoperatively revealed 633 quantifiable proteins, of which 22 showed significant perioperative expression changes. Eight proteins exhibited over two-fold increases, primarily related to the acute phase response (CRP, SAA1, SAA2, LBP), tissue repair (FGL1, A2GL), and anti-inflammatory regulation (AACT). These changes were largely independent of anesthetic type, though SAA2 and MAN1A1 showed anesthetic-specific expression. The upregulation of these proteins implicates the activation of immune pathways involved in host defense, tissue remodeling, and inflammation resolution. <br>\nOur findings provide a molecular reference for the surgical stress response in healthy individuals and highlight candidate biomarkers for predicting and managing postoperative outcomes. Understanding these pathways may support the development of strategies to mitigate surgical stress and enhance recovery, particularly in vulnerable patient populations.dd text (2025)"},"dsDescriptionDate":{"typeName":"dsDescriptionDate","multiple":false,"typeClass":"primitive","value":"2025-05-21"}}]},{"typeName":"subject","multiple":true,"typeClass":"controlledVocabulary","value":["Medicine, Health and Life Sciences"]},{"typeName":"keyword","multiple":true,"typeClass":"compound","value":[{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Surgical stress response"}}]},{"typeName":"topicClassification","multiple":true,"typeClass":"compound","value":[{"topicClassValue":{"typeName":"topicClassValue","multiple":false,"typeClass":"primitive","value":"Anesthesiology"},"topicClassVocab":{"typeName":"topicClassVocab","multiple":false,"typeClass":"primitive","value":"MeSH"},"topicClassVocabURI":{"typeName":"topicClassVocabURI","multiple":false,"typeClass":"primitive","value":"https://www.ncbi.nlm.nih.gov/mesh/68000776"}}]},{"typeName":"publication","multiple":true,"typeClass":"compound","value":[{"publicationCitation":{"typeName":"publicationCitation","multiple":false,"typeClass":"primitive","value":"Brattinga B, Huang H, Maslau S, Thorne AM, Hunter J, Knight S, Struys MMRF, Leuvenink HGD, de Bock GH, Ploeg RJ, Kessler BM, Nieuwenhuijs-Moeke GJ. Effect of a Laparoscopic Donor Nephrectomy in Healthy Living Kidney Donors on the Acute Phase Response Using Either Propofol or Sevoflurane Anesthesia. Int J Mol Sci. 2025 May 28;26(11):5196. doi: 10.3390/ijms26115196. PMID: 40508008; PMCID: PMC12154559."},"publicationIDType":{"typeName":"publicationIDType","multiple":false,"typeClass":"controlledVocabulary","value":"doi"},"publicationIDNumber":{"typeName":"publicationIDNumber","multiple":false,"typeClass":"primitive","value":"10.3390/ijms26115196"},"publicationURL":{"typeName":"publicationURL","multiple":false,"typeClass":"primitive","value":"https://www-mdpi-com.proxy-ub.rug.nl/1422-0067/26/11/5196"}}]},{"typeName":"language","multiple":true,"typeClass":"controlledVocabulary","value":["English"]},{"typeName":"producer","multiple":true,"typeClass":"compound","value":[{"producerName":{"typeName":"producerName","multiple":false,"typeClass":"primitive","value":"Nieuwenhuijs-Moeke, Gertrude Johanna"},"producerAffiliation":{"typeName":"producerAffiliation","multiple":false,"typeClass":"primitive","value":"Department of Anesthesiology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands"},"producerAbbreviation":{"typeName":"producerAbbreviation","multiple":false,"typeClass":"primitive","value":"GJNM"},"producerURL":{"typeName":"producerURL","multiple":false,"typeClass":"primitive","value":"https://umcgresearch.org/w/g-j-nieuwenhuijs-moeke"}}]},{"typeName":"productionDate","multiple":false,"typeClass":"primitive","value":"2012-10-01"},{"typeName":"productionPlace","multiple":true,"typeClass":"primitive","value":["University Medical Center Groningen"]},{"typeName":"contributor","multiple":true,"typeClass":"compound","value":[{"contributorType":{"typeName":"contributorType","multiple":false,"typeClass":"controlledVocabulary","value":"Other"},"contributorName":{"typeName":"contributorName","multiple":false,"typeClass":"primitive","value":"Target Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX1 2JD, UK"}}]},{"typeName":"distributor","multiple":true,"typeClass":"compound","value":[{"distributorName":{"typeName":"distributorName","multiple":false,"typeClass":"primitive","value":"DataverseNL network"},"distributorAffiliation":{"typeName":"distributorAffiliation","multiple":false,"typeClass":"primitive","value":"DANS"},"distributorAbbreviation":{"typeName":"distributorAbbreviation","multiple":false,"typeClass":"primitive","value":"DVNL"},"distributorURL":{"typeName":"distributorURL","multiple":false,"typeClass":"primitive","value":"https://dataverse.nl/"}}]},{"typeName":"distributionDate","multiple":false,"typeClass":"primitive","value":"2025-06-22"},{"typeName":"depositor","multiple":false,"typeClass":"primitive","value":"Silva Correia Alves, Ana"},{"typeName":"dateOfDeposit","multiple":false,"typeClass":"primitive","value":"2025-05-14"},{"typeName":"dateOfCollection","multiple":true,"typeClass":"compound","value":[{"dateOfCollectionStart":{"typeName":"dateOfCollectionStart","multiple":false,"typeClass":"primitive","value":"2010"},"dateOfCollectionEnd":{"typeName":"dateOfCollectionEnd","multiple":false,"typeClass":"primitive","value":"2012"}}]},{"typeName":"kindOfData","multiple":true,"typeClass":"primitive","value":["demographic and outcome data"]},{"typeName":"software","multiple":true,"typeClass":"compound","value":[{"softwareName":{"typeName":"softwareName","multiple":false,"typeClass":"primitive","value":"MS-excel"}}]},{"typeName":"relatedMaterial","multiple":true,"typeClass":"primitive","value":["proteomics data"]},{"typeName":"relatedDatasets","multiple":true,"typeClass":"primitive","value":["DOI: 10.1093/nar/gkae1011"]}]},"dansDataVaultMetadata":{"displayName":"Data Vault Metadata","name":"dansDataVaultMetadata","fields":[{"typeName":"dansDataversePid","multiple":false,"typeClass":"primitive","value":"doi:10.34894/GTKDH6"},{"typeName":"dansDataversePidVersion","multiple":false,"typeClass":"primitive","value":"1.0"},{"typeName":"dansBagId","multiple":false,"typeClass":"primitive","value":"urn:uuid:fdb02d47-3742-4665-be33-cd5d18f47e0a"},{"typeName":"dansNbn","multiple":false,"typeClass":"primitive","value":"urn:nbn:nl:ui:13-b530107e-0ce0-45f6-a7f1-ca17f7b295ba"}]}},"files":[{"label":"Anesthesia and Acute Phase Response in Living Kidney Donors.xlsx","restricted":false,"version":1,"datasetVersionId":30601,"categories":["Data"],"dataFile":{"id":488759,"persistentId":"","filename":"Anesthesia and Acute Phase Response in Living Kidney Donors.xlsx","contentType":"application/vnd.openxmlformats-officedocument.spreadsheetml.sheet","friendlyType":"MS Excel Spreadsheet","filesize":32256,"categories":["Data"],"storageIdentifier":"surf://store:197c18b826e-9fba63b508ed","rootDataFileId":-1,"checksum":{"type":"SHA-1","value":"dda817bef0478fe935c89f2e2797d34ef9ef2514"},"tabularData":false,"creationDate":"2025-06-30","publicationDate":"2025-07-14","lastUpdateTime":"2025-07-14T09:01:17Z","fileAccessRequest":true}}]}}}