{"status":"OK","data":{"id":673687,"identifier":"EFYRM3","persistentUrl":"https://doi.org/10.34894/EFYRM3","protocol":"doi","authority":"10.34894","separator":"/","publisher":"DataverseNL","publicationDate":"2026-09-15","storageIdentifier":"surf://10.34894/EFYRM3","effectiveDatasetFileCountLimit":10000,"datasetFileUploadsAvailable":9982,"datasetType":"dataset","locks":[],"latestVersion":{"id":35348,"datasetId":673687,"datasetPersistentId":"doi:10.34894/EFYRM3","datasetType":"dataset","storageIdentifier":"surf://10.34894/EFYRM3","versionNumber":2,"internalVersionNumber":5,"versionMinorNumber":1,"versionState":"RELEASED","latestVersionPublishingState":"RELEASED","productionDate":"2026-07-30","lastUpdateTime":"2026-09-16T14:22:49Z","releaseTime":"2026-09-16T14:22:49Z","createTime":"2026-09-16T13:49:33Z","publicationDate":"2026-09-15","citationDate":"2026-09-15","effectiveDatasetFileCountLimit":10000,"datasetFileUploadsAvailable":9982,"termsOfUse":"The standard Data Sharing Agreement (DSA) of the UMC Utrecht must be signed without adjustments. 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The Data Sharing Agreement is signed by both parties.","citationRequirements":"Read <a href=\"https://www.umcutrecht.nl/en/research-data-umc-utrecht\">here</a>  for more information about the data request proces and the Data Sharing Agreement. The Data Sharing Agreement is signed by both parties.","conditions":"To access and use the dataset please read the Terms of Use and the Terms of Access for Restricted Files.","disclaimer":"Read <a href=\"https://www.umcutrecht.nl/en/research-data-umc-utrecht\">here</a>  for more information about the data request proces and the Data Sharing Agreement. The Data Sharing Agreement is signed by both parties.","termsOfAccess":"The data is not available for download directly via DataverseNL. Data is available on request by completing the <a href=\"https://www.umcutrecht.nl/en/data-request-form-umc-utrecht\">request form</a>. Only data requests in line with the Terms of Use will be taken into consideration. In addition to a completed request form, the Data Sharing Agreement (DSA) in line with GDPR regulations and/or the Research Collaboration Agreement (RCA) should be signed before data is shared. If a data request is approved, the data will be delivered in a safe and secure manner. By signing the DSA and/or RCA and accessing the Materials, the recipient represents his/her acceptance of the Terms of Use.  ","availabilityStatus":"The data is not available for download directly via DataverseNL but is available on request if the request is compliant with the Terms of Access. ","contactForAccess":"Please fill out the <a href=\"https://www.umcutrecht.nl/en/data-request-form-umc-utrecht\">request form</a>.","fileAccessRequest":false,"metadataBlocks":{"citation":{"displayName":"Citation Metadata","name":"citation","fields":[{"typeName":"title","multiple":false,"typeClass":"primitive","value":"Prediction Aided Tapering In rheumatoid arthritis patients treated with biOlogicals (PATIO): a randomised controlled trial"},{"typeName":"author","multiple":true,"typeClass":"compound","value":[{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Welsing, Paco Mattheus Jacobus"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"UMC Utrecht"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"https://orcid.org/0000-0003-2361-2803"}}]},{"typeName":"datasetContact","multiple":true,"typeClass":"compound","value":[{"datasetContactName":{"typeName":"datasetContactName","multiple":false,"typeClass":"primitive","value":"Datamanagement Datamanagement Internal Medicine and Dermatology"},"datasetContactAffiliation":{"typeName":"datasetContactAffiliation","multiple":false,"typeClass":"primitive","value":"UMC Utrecht"}}]},{"typeName":"dsDescription","multiple":true,"typeClass":"compound","value":[{"dsDescriptionValue":{"typeName":"dsDescriptionValue","multiple":false,"typeClass":"primitive","value":"Objectives:To evaluate whether prediction-aided tapering of bDMARDs reduces flare occurrence compared with disease activity–guided dose optimisation (DGDO) in patients with rheumatoid arthritis (RA) and sustained low disease activity.\nMethods: PATIO was a pragmatic, multicentre, open-label, randomised controlled superiority trial. RA patients receiving stable bDMARD therapy with stable controlled disease,  eligible for tapering were randomised 1:1 to DGDO alone or DGDO supported by a previously validated dynamic prediction model estimating 3-monthly flare risk. Follow-up was 18 months. The primary outcome was the flare rate per patient. Secondary outcomes included any flare, major flares (>12 weeks), DAS28-CRP over time, mean bDMARD dose fraction, infections, and patient-reported outcomes. \nResults: A total of 162 patients were included (81 per group). Over 18 months, the mean number of flares per patient was 1.00 (95% CI 0.73–1.27) in the prediction-aided group and 0.73 (95% CI 0.51–0.95) in the DGDO group (rate ratio 1.32, 95% CI 0.90–1.957. Any flare occurred in 57% of prediction-aided and 44% of DGDO patients, and major flares in 22% and 15%, respectively. DAS28-CRP trajectories, mean bDMARD dose reduction, patient-reported outcomes, and infection rates were similar between strategies. Non-adherence to tapering advice occurred in 23% of visits: 72% of these regarded advice to continue tapering, and 28% advice to stop tapering or escalate medication. \nConclusion: Prediction-aided bDMARD tapering using this model did not improve flare rates or medication use. Prediction models require sufficient, robust accuracy and prospective evaluation before implementation."},"dsDescriptionDate":{"typeName":"dsDescriptionDate","multiple":false,"typeClass":"primitive","value":"2026-09-10"}}]},{"typeName":"subject","multiple":true,"typeClass":"controlledVocabulary","value":["Medicine, Health and Life Sciences"]},{"typeName":"keyword","multiple":true,"typeClass":"compound","value":[{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"RCT"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Rheumatoid Arthritis"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Biological DMARD tapering"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Decision support"}}]},{"typeName":"publication","multiple":true,"typeClass":"compound","value":[{"publicationRelationType":{"typeName":"publicationRelationType","multiple":false,"typeClass":"controlledVocabulary","value":"References"},"publicationCitation":{"typeName":"publicationCitation","multiple":false,"typeClass":"primitive","value":"Messelink MA, van der Leeuw MS, den Broeder AA, Tekstra J, van der Goes MC, Heijstek MW, Lafeber F, Welsing PMJ. Prediction Aided Tapering In rheumatoid arthritis patients treated with biOlogicals (PATIO): protocol for a randomized controlled trial. Trials. 2022 Jun 16;23(1):494. doi: 10.1186/s13063-022-06471-x.  PMCID: PMC9202120."},"publicationIDType":{"typeName":"publicationIDType","multiple":false,"typeClass":"controlledVocabulary","value":"pmid"},"publicationIDNumber":{"typeName":"publicationIDNumber","multiple":false,"typeClass":"primitive","value":"35710576"}}]},{"typeName":"productionDate","multiple":false,"typeClass":"primitive","value":"2026-07-30"},{"typeName":"productionPlace","multiple":true,"typeClass":"primitive","value":["The Netherlands, Utrecht region."]},{"typeName":"contributor","multiple":true,"typeClass":"compound","value":[{"contributorType":{"typeName":"contributorType","multiple":false,"typeClass":"controlledVocabulary","value":"Research Group"}}]},{"typeName":"grantNumber","multiple":true,"typeClass":"compound","value":[{"grantNumberAgency":{"typeName":"grantNumberAgency","multiple":false,"typeClass":"primitive","value":"ZonMW"},"grantNumberValue":{"typeName":"grantNumberValue","multiple":false,"typeClass":"primitive","value":"848018009"}}]},{"typeName":"depositor","multiple":false,"typeClass":"primitive","value":"Welsing, Paco Mattheus Jacobus"},{"typeName":"dateOfDeposit","multiple":false,"typeClass":"primitive","value":"2026-09-10"},{"typeName":"dateOfCollection","multiple":true,"typeClass":"compound","value":[{"dateOfCollectionStart":{"typeName":"dateOfCollectionStart","multiple":false,"typeClass":"primitive","value":"2021-11-10"},"dateOfCollectionEnd":{"typeName":"dateOfCollectionEnd","multiple":false,"typeClass":"primitive","value":"2026-07-15"}}]},{"typeName":"kindOfData","multiple":true,"typeClass":"primitive","value":["clinical data"]},{"typeName":"software","multiple":true,"typeClass":"compound","value":[{"softwareName":{"typeName":"softwareName","multiple":false,"typeClass":"primitive","value":"Castor EDC"}}]},{"typeName":"accessToSources","multiple":false,"typeClass":"primitive","value":"The (raw) data can be of interest for other researchers or for spin off projects. Data cannot be reused without consulting the study team. In the event that peers like to reuse our data this can only be granted if the research question is in line with the original research question of our research (according to informed consent). Every application therefore will be screened upon (a.o.) this requirement by the\nstudy team. contact details for this are: p.m.j.welsing@umcutrecht.nl"}]},"dansDataVaultMetadata":{"displayName":"Data Vault Metadata","name":"dansDataVaultMetadata","fields":[{"typeName":"dansDataversePid","multiple":false,"typeClass":"primitive","value":"doi:10.34894/EFYRM3"},{"typeName":"dansDataversePidVersion","multiple":false,"typeClass":"primitive","value":"2.1"},{"typeName":"dansBagId","multiple":false,"typeClass":"primitive","value":"urn:uuid:5d6b22e5-991f-493a-b5c6-33715f841ba2"},{"typeName":"dansNbn","multiple":false,"typeClass":"primitive","value":"urn:nbn:nl:ui:13-e9df4398-6b88-406f-96a1-f893564f6775"}]}},"files":[{"label":"comments.csv","restricted":true,"version":1,"datasetVersionId":35348,"dataFile":{"id":674088,"persistentId":"","filename":"comments.csv","contentType":"text/csv","friendlyType":"Comma Separated 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