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Despite current treatments, it is associated with high risk of recurrence and/or progression. Metformin is effective against bladder cancer in animal models. The objective of this multicenter, open-label, phase 2 study is to determine the complete response rate of bladder cancer to administration of oral metformin for 3 months in ablating a marker tumour deliberately left following transurethral resection of multiple, papillary tumours in the bladder. Secondary outcomes are the partial response rate, overal saftety of metformin and the duration of time to recurrence after marker lesion resection."},"dsDescriptionDate":{"typeName":"dsDescriptionDate","multiple":false,"typeClass":"primitive","value":"2024-11-18"}}]},{"typeName":"subject","multiple":true,"typeClass":"controlledVocabulary","value":["Medicine, Health and Life Sciences"]},{"typeName":"keyword","multiple":true,"typeClass":"compound","value":[{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Bladder cancer"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Metformin"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Amsterdam UMC"}}]},{"typeName":"topicClassification","multiple":true,"typeClass":"compound","value":[{"topicClassValue":{"typeName":"topicClassValue","multiple":false,"typeClass":"primitive","value":"Bladder cancer"}},{"topicClassValue":{"typeName":"topicClassValue","multiple":false,"typeClass":"primitive","value":"Metformin"}}]},{"typeName":"language","multiple":true,"typeClass":"controlledVocabulary","value":["English"]},{"typeName":"productionDate","multiple":false,"typeClass":"primitive","value":"2019-09-03"},{"typeName":"productionPlace","multiple":true,"typeClass":"primitive","value":["Amsterdam UMC"]},{"typeName":"grantNumber","multiple":true,"typeClass":"compound","value":[{"grantNumberAgency":{"typeName":"grantNumberAgency","multiple":false,"typeClass":"primitive","value":"ZonMW"},"grantNumberValue":{"typeName":"grantNumberValue","multiple":false,"typeClass":"primitive","value":"848082004"}}]},{"typeName":"depositor","multiple":false,"typeClass":"primitive","value":"Remmelink, Marinka"},{"typeName":"dateOfDeposit","multiple":false,"typeClass":"primitive","value":"2024-11-18"},{"typeName":"dateOfCollection","multiple":true,"typeClass":"compound","value":[{"dateOfCollectionStart":{"typeName":"dateOfCollectionStart","multiple":false,"typeClass":"primitive","value":"2019-05-07"},"dateOfCollectionEnd":{"typeName":"dateOfCollectionEnd","multiple":false,"typeClass":"primitive","value":"2024-09-27"}}]},{"typeName":"kindOfData","multiple":true,"typeClass":"primitive","value":["Metadata (protocol, data management plan)"]}]},"dansDataVaultMetadata":{"displayName":"Data Vault Metadata","name":"dansDataVaultMetadata","fields":[{"typeName":"dansDataversePid","multiple":false,"typeClass":"primitive","value":"doi:10.34894/B5OD0M"},{"typeName":"dansDataversePidVersion","multiple":false,"typeClass":"primitive","value":"1.0"},{"typeName":"dansBagId","multiple":false,"typeClass":"primitive","value":"urn:uuid:ae7958a9-486a-473f-b05a-bc0e2a579d10"},{"typeName":"dansNbn","multiple":false,"typeClass":"primitive","value":"urn:nbn:nl:ui:13-b69d92f0-b4a6-4b99-8e32-13d6c7e9693b"}]}},"files":[{"description":"Protocol of the TROJAN study","label":"C1 TROJAN protocol versie 1.3 september 2019.pdf","restricted":false,"version":1,"datasetVersionId":29892,"dataFile":{"id":458628,"persistentId":"","filename":"C1 TROJAN protocol versie 1.3 september 2019.pdf","contentType":"application/pdf","friendlyType":"Adobe PDF","filesize":615475,"description":"Protocol of the TROJAN study","storageIdentifier":"surf://store:1933f9b9364-5b9c324dbac4","rootDataFileId":-1,"checksum":{"type":"SHA-1","value":"c7fb607c157096644e005ddbd1bb85ec98ee3610"},"tabularData":false,"creationDate":"2024-11-18","publicationDate":"2024-11-18","lastUpdateTime":"2024-11-18T15:14:51Z","fileAccessRequest":true}},{"description":"Data management plan of the TROJAN study","label":"DMP_TROJAN.pdf","restricted":false,"version":1,"datasetVersionId":29892,"dataFile":{"id":458627,"persistentId":"","filename":"DMP_TROJAN.pdf","contentType":"application/pdf","friendlyType":"Adobe PDF","filesize":168822,"description":"Data management plan of the TROJAN study","storageIdentifier":"surf://store:1933f9c950b-0dac053fbcd2","rootDataFileId":-1,"checksum":{"type":"SHA-1","value":"43e7e7e97992ecb7b6b27566f05dbd20df96b8e9"},"tabularData":false,"creationDate":"2024-11-18","publicationDate":"2024-11-18","lastUpdateTime":"2024-11-18T15:14:51Z","fileAccessRequest":true}}]}}}