{"status":"OK","data":{"id":314570,"identifier":"AUUSS2","persistentUrl":"https://doi.org/10.34894/AUUSS2","protocol":"doi","authority":"10.34894","separator":"/","publisher":"DataverseNL","publicationDate":"2022-10-19","storageIdentifier":"surf://10.34894/AUUSS2","effectiveDatasetFileCountLimit":10000,"datasetFileUploadsAvailable":9996,"datasetType":"dataset","locks":[],"latestVersion":{"id":24377,"datasetId":314570,"datasetPersistentId":"doi:10.34894/AUUSS2","datasetType":"dataset","storageIdentifier":"surf://10.34894/AUUSS2","versionNumber":1,"internalVersionNumber":21,"versionMinorNumber":0,"versionState":"RELEASED","latestVersionPublishingState":"RELEASED","deaccessionLink":"","lastUpdateTime":"2022-10-19T13:09:05Z","releaseTime":"2022-10-19T13:09:05Z","createTime":"2022-10-18T11:08:29Z","publicationDate":"2022-10-19","citationDate":"2022-10-19","effectiveDatasetFileCountLimit":10000,"datasetFileUploadsAvailable":9996,"termsOfUse":"The standard Data Sharing Agreement (DSA) of the UMC Utrecht must be signed without adjustments. 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","fileAccessRequest":false,"metadataBlocks":{"citation":{"displayName":"Citation Metadata","name":"citation","fields":[{"typeName":"title","multiple":false,"typeClass":"primitive","value":"Abdominal Aortic Aneurysm-Express Biobank Study (database including clinical data)"},{"typeName":"author","multiple":true,"typeClass":"compound","value":[{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Sander W. van der Laan"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"UMC Utrecht"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0000-0001-6888-1404"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Gerard Pasterkamp"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"UMC Utrecht"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Gert Jan de Borst"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"UMC Utrecht"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Dominique P.V. de Kleijn"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"UMC Utrecht"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0000-0003-2714-2140"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Joost A. van Herwaarden"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"UMC Utrecht"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0000-0003-1165-5179"}}]},{"typeName":"datasetContact","multiple":true,"typeClass":"compound","value":[{"datasetContactName":{"typeName":"datasetContactName","multiple":false,"typeClass":"primitive","value":"dLAB Data Management"},"datasetContactAffiliation":{"typeName":"datasetContactAffiliation","multiple":false,"typeClass":"primitive","value":"UMC Utrecht"}},{"datasetContactName":{"typeName":"datasetContactName","multiple":false,"typeClass":"primitive","value":"Sander W. van der Laan"},"datasetContactAffiliation":{"typeName":"datasetContactAffiliation","multiple":false,"typeClass":"primitive","value":"UMC Utrecht"}}]},{"typeName":"dsDescription","multiple":true,"typeClass":"compound","value":[{"dsDescriptionValue":{"typeName":"dsDescriptionValue","multiple":false,"typeClass":"primitive","value":"<strong>Background</strong></br>\n<strong>The Abdominal Aortic Aneurysm-Express Biobank Study (AAA)</strong> started in 2003 and and now includes over 1,000 patients who underwent open surgical repair of arterial aneurysms, the majority on aortic aneurysms at two Dutch tertiary referral centers. Details of the study design were described <a href=\"https://doi.org/10.1159/000318160\" target=\"_blank\">before</a>. Briefly, blood and aneurysm material were obtained during surgery and stored at -80℃; tissue material is routinely used for <a href=\"https://doi.org/10.1159/000318160\" target=\"_blank\">standardised (immuno)histochemical analysis</a>. We routinely perform the following stainings: hematoxilin & eosin (HE),\nelastic van Giesson (EVG), picro sirius red (collagen),  smooth muscle alpha-actin (SMA, smooth-muscle cells), CD68 (macrophages), CD3\n(T lymphocytes), CD20 (B lymphocytes), CD138 (plasma cells)\nand von Willebrand factor (vasa vasorum). All stainings are\nscored semiquantitatively on a scale from 0 to 3 (0 being no staining, 1 minor, 2 moderate and 3 heavy staining). Structural wall\ncomponents (elastin, collagen, vasa vasorum) and cells (smoothmuscle cells, macrophages, T lymphocytes, B lymphocytes and\nplasma cells) are scored on a 0 to 3 scale separately for intima,\nmedia and adventitia. All histological observations were performed by the same dedicated technician. Clinical data is collected through standardised questionnaires and supplemented by querying electronic health records when needed.</br>\n</br>\nEthical approval for this study (TME/C-01.18) was provided by the Medical Research Ethics Committee of University Medical Center Utrecht, Utrecht, The Netherlands on 10 April 2002, and all research was conducted according to the principles of the Declaration of Helsinki (59th amendment, Seoul 2008) and in accordance with the Dutch Medical Research Involving Human Subjects Act (WMO). </br>\n</br>\n<b>Important notice on availability of data</b></br>\n- Whole-slide images (WSI) are available for the (immuno)histochemical stainings. The amount of data is huge, on average 1Gb size per WSI. These are accessible through <a href=\"https://doi.org/10.34894/QI135J\" target=\"_blank\"><strong>ExpressScan</strong></a>.</br>\n- Genetic (GWAS chip) data are described <a href=\"https://doi.org/10.1159/000318160\" target=\"_blank\">here</a> and accessible through <a href=\"#\" target=\"_blank\">this repository [NOT AVAILABLE YET]</a>.</br>\n</br>\n</br>\nThere are restrictions on use by commercial parties, and on sharing openly based on (inter)national laws and regulations and the written informed consent. Therefore these data (and additional clinical data) are only available upon discussion and signing a Data Sharing Agreement (see Terms of Access) and within a specially designed UMC Utrecht provided environment.</br></br>"},"dsDescriptionDate":{"typeName":"dsDescriptionDate","multiple":false,"typeClass":"primitive","value":"2022-10-18"}}]},{"typeName":"subject","multiple":true,"typeClass":"controlledVocabulary","value":["Medicine, Health and Life Sciences"]},{"typeName":"keyword","multiple":true,"typeClass":"compound","value":[{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"aneurysm"}}]},{"typeName":"publication","multiple":true,"typeClass":"compound","value":[{"publicationCitation":{"typeName":"publicationCitation","multiple":false,"typeClass":"primitive","value":"<a href=\"https://doi.org/10.1159/000318160\">Hurks, R. <em>et al.</em></a> Aneurysm-Express: Human Abdominal Aortic Aneurysm Wall Expression in Relation to Heterogeneity and Vascular Events – Rationale and Design. <strong>Eur Surg Res</strong> 45:34–40 (2010).</br>"},"publicationIDType":{"typeName":"publicationIDType","multiple":false,"typeClass":"controlledVocabulary","value":"doi"},"publicationIDNumber":{"typeName":"publicationIDNumber","multiple":false,"typeClass":"primitive","value":"10.1159/000318160"},"publicationURL":{"typeName":"publicationURL","multiple":false,"typeClass":"primitive","value":"https://doi.org/10.1159/000318160"}},{"publicationCitation":{"typeName":"publicationCitation","multiple":false,"typeClass":"primitive","value":"<a href=\"https://doi.org/10.1159/000318160\">van Laarhoven, C.J.H.C.M. <em>et al.</em></a> Polygenic Susceptibility of Aortic Aneurysms Associates to the Diameter of the Aneurysm Sac: the Aneurysm-Express Biobank Cohort. <strong>Sci Rep</strong> 9, 19844 (2019). </br>"},"publicationIDType":{"typeName":"publicationIDType","multiple":false,"typeClass":"controlledVocabulary","value":"doi"},"publicationIDNumber":{"typeName":"publicationIDNumber","multiple":false,"typeClass":"primitive","value":"10.1038/s41598-019-56230-3"},"publicationURL":{"typeName":"publicationURL","multiple":false,"typeClass":"primitive","value":"https://doi.org/10.1038/s41598-019-56230-3"}}]},{"typeName":"depositor","multiple":false,"typeClass":"primitive","value":"van der Laan, Sander W."},{"typeName":"dateOfDeposit","multiple":false,"typeClass":"primitive","value":"2022-10-18"}]},"dansDataVaultMetadata":{"displayName":"Data Vault 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