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In this in vitro cell experiment, C2C12 myoblasts were proliferated for 24h and differentiated for 120h while exposed to different concentrations of hesperetin (5, 20, 50μM), ellagic acid (0.05, 0.1μM) or a combination (20μM hesperetin, 0.05μM, 20 ellagic acid) in the absence and presence of oxidative stress-inducing compound menadione (9μM) during 24h of proliferation and during the first 5h of differentiation. The number of proliferating cells was assessed using fluorescent labelling of incorporated 5-ethynyl-2’-deoxyuridine (EdU). Myosin heavy chain (MyHC) expression was assessed by fluorescence microscopy and muscle cell fusion index was calculated as the number of nuclei inside MyHC-positive myotubes as a percentage of the total number of nuclei. 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